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Central Nervous System Infection Diagnosis by Next-Generation Sequencing A Glimpse Into the Future.pdf (173.36 kB)

Central nervous system infection diagnosis by next-generation sequencing: a glimpse into the future?

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posted on 2023-06-10, 02:24 authored by Nguyen T H Mai, Nguyen H Phu, Le Nguyen T Nhu, Nguyen T T Hong, Nguyen H H Hanh, Lam A Nguyet, Tran M Phuong, Angela McBride, Do Quang Ha, Ho D T Nghia, Nguyen V V Chau, Guy Thwaites, Le Van Tan
Japanese encephalitis virus was detected by deep sequencing for the first time in urine of a 16-year-old boy with encephalitis. Seroconversion and polymerase chain reaction analysis confirmed the metagenomics finding. Urine is useful for diagnosis of flaviviral encephalitis, whereas deep sequencing can be a panpathogen assay for the diagnosis of life-threatening infectious diseases.

History

Publication status

  • Published

File Version

  • Published version

Journal

Open Forum Infectious Diseases

ISSN

2328-8957

Publisher

Oxford University Press (OUP)

External DOI

Issue

2

Volume

4

Page range

ofx046 1-3

Event location

United States

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2022-09-30

First Open Access (FOA) Date

2022-09-30

First Compliant Deposit (FCD) Date

2022-09-29

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    University of Sussex (Publications)

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    Keywords

    Japanese encephalitis virusVietnamdeep sequencing

    Licence

    CC BY 4.0

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