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Effects of curcumin-piperine supplementation on systemic immunity in young women with premenstrual syndrome and dysmenorrhea: a randomized clinical trial
journal contribution
posted on 2023-06-10, 04:47 authored by Afsane Bahrami, Mahtab Mohamadifard, Zahra Rajabi, Mohammadhossein Matahari-Nasab, Gordon FernsGordon FernsIntroduction Premenstrual syndrome (PMS) and primary dysmenorrhea (PD) are common gynecological complications and there is evidence that inflammation may be an important factor in their etiology. There is a relationship between PMS and PD with susceptibility to allergic disorders. We aimed to assess the effect of curcumin co-administered with piperine on serum IL-10, IL-12 and IgE levels in patients with PD and PMS. Materials and Methods A sample of 80 patients were recruited to this triple-blind, placebo-controlled clinical trial. Participants were randomly allocated to curcumin (n=40) and control groups (n=40). Each participant received one capsule (500 mg of curcuminoid plus piperine, or placebo) daily, from 7 days before until 3 days after menstruation for three consecutive menstrual cycles. Results Serum IgE, IL-10 and IL-12 levels were quantified by using an ELISA kit. No significant differences were found between the two groups at baseline, including: age, BMI, and dietary intakes (P>0.05). Curcumin+piperine treatment was associated with a significant reduction in the mean serum levels of IgE [from 223.6±258.7 IU/mL to 161.3±240.7; P=0.001]; but there were no significant changes in the placebo group (P=0.12). Serum concentrations of IL-10 and IL-12 before and after the trial period did not differ significantly between the two groups (P>0.05). Conclusion Curcumin plus piperine might be have positive effect on serum IgE levels with no significant changes on serum IL-10 and IL-12 in healthy young women with PMS and PD. Studies with higher doses and longer durations of treatment with curcumin are required to confirm these findings.
History
Publication status
- Published
File Version
- Accepted version
Journal
European Journal of Obstetrics & Gynaecologial Reproduction & BiologyISSN
0301-2115Publisher
ElsevierExternal DOI
Volume
278Page range
131-136Department affiliated with
- Division of Medical Education Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2022-09-22First Compliant Deposit (FCD) Date
2022-09-22Usage metrics
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