University of Sussex
Browse
GF accepted manuscript.pdf (503.25 kB)

Effects of curcumin-piperine supplementation on systemic immunity in young women with premenstrual syndrome and dysmenorrhea: a randomized clinical trial

Download (503.25 kB)
journal contribution
posted on 2023-06-10, 04:47 authored by Afsane Bahrami, Mahtab Mohamadifard, Zahra Rajabi, Mohammadhossein Matahari-Nasab, Gordon FernsGordon Ferns
Introduction Premenstrual syndrome (PMS) and primary dysmenorrhea (PD) are common gynecological complications and there is evidence that inflammation may be an important factor in their etiology. There is a relationship between PMS and PD with susceptibility to allergic disorders. We aimed to assess the effect of curcumin co-administered with piperine on serum IL-10, IL-12 and IgE levels in patients with PD and PMS. Materials and Methods A sample of 80 patients were recruited to this triple-blind, placebo-controlled clinical trial. Participants were randomly allocated to curcumin (n=40) and control groups (n=40). Each participant received one capsule (500 mg of curcuminoid plus piperine, or placebo) daily, from 7 days before until 3 days after menstruation for three consecutive menstrual cycles. Results Serum IgE, IL-10 and IL-12 levels were quantified by using an ELISA kit. No significant differences were found between the two groups at baseline, including: age, BMI, and dietary intakes (P>0.05). Curcumin+piperine treatment was associated with a significant reduction in the mean serum levels of IgE [from 223.6±258.7 IU/mL to 161.3±240.7; P=0.001]; but there were no significant changes in the placebo group (P=0.12). Serum concentrations of IL-10 and IL-12 before and after the trial period did not differ significantly between the two groups (P>0.05). Conclusion Curcumin plus piperine might be have positive effect on serum IgE levels with no significant changes on serum IL-10 and IL-12 in healthy young women with PMS and PD. Studies with higher doses and longer durations of treatment with curcumin are required to confirm these findings.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

European Journal of Obstetrics & Gynaecologial Reproduction & Biology

ISSN

0301-2115

Publisher

Elsevier

Volume

278

Page range

131-136

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2022-09-22

First Compliant Deposit (FCD) Date

2022-09-22

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC