Effects of curcumin-piperine supplementation on systemic immunity in young women with premenstrual syndrome and dysmenorrhea: a randomized clinical trial

Bahrami, Afsane, Mohamadifard, Mahtab, Rajabi, Zahra, Matahari-Nasab, Mohammadhossein and Ferns, Gordon (2022) Effects of curcumin-piperine supplementation on systemic immunity in young women with premenstrual syndrome and dysmenorrhea: a randomized clinical trial. European Journal of Obstetrics & Gynaecologial Reproduction & Biology, 278. pp. 131-136. ISSN 0301-2115

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Abstract

Introduction
Premenstrual syndrome (PMS) and primary dysmenorrhea (PD) are common gynecological complications and there is evidence that inflammation may be an important factor in their etiology. There is a relationship between PMS and PD with susceptibility to allergic disorders. We aimed to assess the effect of curcumin co-administered with piperine on serum IL-10, IL-12 and IgE levels in patients with PD and PMS.

Materials and Methods
A sample of 80 patients were recruited to this triple-blind, placebo-controlled clinical trial. Participants were randomly allocated to curcumin (n=40) and control groups (n=40). Each participant received one capsule (500 mg of curcuminoid plus piperine, or placebo) daily, from 7 days before until 3 days after menstruation for three consecutive menstrual cycles.

Results
Serum IgE, IL-10 and IL-12 levels were quantified by using an ELISA kit. No significant differences were found between the two groups at baseline, including: age, BMI, and dietary intakes (P>0.05). Curcumin+piperine treatment was associated with a significant reduction in the mean serum levels of IgE [from 223.6±258.7 IU/mL to 161.3±240.7; P=0.001]; but there were no significant changes in the placebo group (P=0.12). Serum concentrations of IL-10 and IL-12 before and after the trial period did not differ significantly between the two groups (P>0.05).

Conclusion
Curcumin plus piperine might be have positive effect on serum IgE levels with no significant changes on serum IL-10 and IL-12 in healthy young women with PMS and PD. Studies with higher doses and longer durations of treatment with curcumin are required to confirm these findings.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 22 Sep 2022 08:39
Last Modified: 02 Nov 2022 15:15
URI: http://sro.sussex.ac.uk/id/eprint/108057

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