Case series: a single-centre experience of post COVID-19 vaccine related immune-mediated complications

The significant impact of the COVID-19 pandemic has resulted in a worldwide effort to develop effective vaccines. In the United Kingdom, the COVID-19 vaccine development and roll-out has been overwhelmingly successful in reducing infections and deaths. However, case reports have emerged of a rare syndrome of vaccine-induced immune thrombocytopenia and thrombosis (VITT), as well as cases of immune thrombocytopenia (ITP). This has necessitated a better understanding of these conditions. However, as both VITT and ‘vaccine-associated ITP’ are emerging conditions, evidence on the clinical features, epidemiology and management is still evolving. Subsequently, with the initiation of the COVID-19 vaccine booster-program, it has become increasingly important to continue to collect accurate data on post COVID-19 vaccine complications to aid with their prompt recognition and management. In this case series we report on the presentations and management of eight cases of post COVID-19 vaccine related immune-mediated complications which occurred at our centre between the months of March and July 2021.