Enhanced external counterpulsation does not alter arterial stiffness in patients with angina

Dockery, F, Rajkumar, C, Bulpitt, CJ, Hall, RJ and Bagger, JP (2004) Enhanced external counterpulsation does not alter arterial stiffness in patients with angina. Clinical Cardiology, 27. pp. 689-692. ISSN 0160-9289

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Background: Enhanced external counterpulsation (EECP) is a noninvasive treatment for angina that acutely augments diastolic pressure and reduces cardiac afterload. However, the mechanism of the sustained clinical benefit seen with this therapy is not known. Hypothesis: The study aimed to determine whether EECP leads to an improvement in arterial stiffness. Methods: In all, 22 men and 1 woman with angina (age 63.6 ± 6.7 years, mean ± SD) were studied prior to and after 35 h of EECP therapy over 7 weeks. We measured carotid-radial (C-R) pulse wave velocity (PWV), and aortic augmentation index (AI) was derived from radial and carotid artery waveforms using applanation tonometry. Seventeen patients underwent treadmill exercise testing before and after the 7 weeks of EECP Results: After EECP therapy, despite a significant improvement in treadmill exercise time and a reduction in systolic and diastolic blood, pressures, there was no significant change in any arterial stiffness parameters: Mean C-R PWV was 8.4 ± 0.8 m/s at baseline and 8.0 ± 1.2 m/s after 7 weeks of EECP, mean change: -0.4, 95% confidence interval (CI): -1.0, + 0.2, p = 0.17. Mean radial-derived AI was 25.7 ± 10.4% before and 24.6 ± 10.8% after, mean change: + 1.1%, 95% CI: -2.3, + 4.5, p = 0.53. Median AI-carotid was 31.5% before and 28.7% after; median change: -0.5, interquartile range: -9.5, + 3.5, p = 0.32. Nineteen patients returned for 6-month recordings; neither blood pressure nor arterial stiffness readings were significantly different from baseline. Conclusion: Enhanced external counterpulsation therapy does not significantly alter arterial stiffness. Other than an initial reduction in blood pressure, the sustained clinical benefit seen with this therapy is unlikely to be effected through alterations in arterial wall mechanical properties.

Item Type: Article
Keywords: Aged, Angina Pectoris, Blood Pressure, Carotid Arteries, Coronary Angiography, Counterpulsation, Echocardiography, Stress, Electrocardiography, Exercise Test, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Contraction, Radial Artery
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 07 Sep 2022 12:44
Last Modified: 07 Sep 2022 12:44
URI: http://sro.sussex.ac.uk/id/eprint/107777
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