The aging of elastic and muscular arteries: A comparison of diabetic and nondiabetic subjects

Cameron, JD, Bulpitt, CJ, Pinto, ES and Rajkumar, C (2003) The aging of elastic and muscular arteries: A comparison of diabetic and nondiabetic subjects. Diabetes Care, 26. pp. 2133-2138. ISSN 0149-5992

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Abstract

Objective
To compare age-related changes in the mechanical properties of different arterial segments in normal volunteers and subjects with type 2 diabetes.

Research Design and Methods
In 169 subjects (diabetic n = 57 and nondiabetic n = 112), we assessed the mechanical properties of three arterial segments of differing wall composition. Pulse wave velocity (PWV) was measured noninvasively in a thoraco-abdominal segment (carotid femoral PWV [PWVcf]), in an upper limb muscular artery (carotid radial PWV [PWVcr]), and from the aorta to the finger (PWV from the aorta to the finger [PWVfin]). Central aortic compliance (CAC) was also measured.

Results
Average CAC was lower (0.662 vs. 0.850, P < 0.05) and all measures of PWV tended to be faster in diabetic subjects despite the fact that they were, on average, 10 years younger. However, these measures were not related to age in diabetic subjects. After correcting for blood pressure, only PWVcf was associated with age in nondiabetic subjects (P < 0.001). Expressing results as ratios of nonelastic to elastic arterial segments (i.e., PWVcr-to-PWVcf and PWVfin-to-PWVcf) improved the relationship with age. Both PWVcr-to-PWVcf and PWVfin-to-PWVcf were significantly associated with age in nondiabetic subjects (r = −0.59, P < 0.001; r = −0.57, P < 0.001) but not in diabetic subjects (r = −0.15, P = 0.302; r = −0.24, P = 0.129). Multivariate analysis showed that the ratios were not associated with systolic blood pressure.

Conclusions
There are significant differences in the rate of age-related decline in vascular stiffness in elastic arteries of nondiabetic compared with diabetic arteries. Diabetic arteries appear to age at an accelerated rate at an earlier age and then reach a functional plateau.

Item Type: Article
Keywords: Adult, Aged, Aged, 80 and over, Aging, Arteries, Blood Pressure, Body Weight, Carotid Arteries, Diabetes Mellitus, Type 2, Elasticity, Female, Humans, Male, Middle Aged, Muscle, Smooth, Vascular, Pulse, Reference Values
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 07 Sep 2022 12:51
Last Modified: 07 Sep 2022 12:51
URI: http://sro.sussex.ac.uk/id/eprint/107776
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