Fetuin-A is an independent determinant of change of aortic stiffness over 1 year in non-diabetic patients with CKD stages 3 and 4

Ford, ML, Tomlinson, LA, Smith, ER, Rajkumar, C and Holt, SG (2010) Fetuin-A is an independent determinant of change of aortic stiffness over 1 year in non-diabetic patients with CKD stages 3 and 4. Nephrology Dialysis Transplantation, 25. pp. 1853-1858. ISSN 0931-0509

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Background. Vascular calcification is highly prevalent in chronic kidney disease (CKD) patients. This calcification leads to arterial stiffening. Fetuin-A is an endogenous inhibitor of vascular calcification and has been associated with arterial stiffness and mortality in dialysis patients. We tested the relationship between fetuin-A and change in arterial stiffness in CKD stages 3 and 4.Methods. We measured fetuin-A concentrations in 92 patients with CKD stages 3 and 4 and studied the association with clinical, biochemical and vascular parameters including arterial stiffness measured by carotid-femoral pulse wave velocity (PWV) at 0 and 12 months.Results. Fetuin-A was significantly lower in the non-diabetic group (n = 73) compared to the diabetic group (n = 19, P = 0.018). There was a significant interaction between diabetic status and fetuin-A concentration. Univariate analysis of the non-diabetic group showed association between change in aortic stiffness over 1 year with fetuin-A (r =-0.481, P < 0.0001) and systolic blood pressure (r = 0.389, P = 0.001) and baseline PWV (r = 0.240, P = 0.041). In multivariate analysis, fetuin-A, systolic blood pressure and baseline PWV independently predicted change in carotid-femoral PWV at 1 year (β =-0.355, P = < 0.001; β = 0.426, P < 0.001; and β =-0.383, P < 0.001, respectively; model R2 = 0.455).Conclusions. In patients with non-diabetic CKD stages 3 and 4, fetuin-A is an independent risk factor for progressive arterial stiffness. © 2010 The Author.

Item Type: Article
Keywords: Aged, Aorta, Blood Pressure, Blood Proteins, C-Reactive Protein, Calcinosis, Cohort Studies, Disease Progression, Female, Humans, Male, Middle Aged, Prospective Studies, Pulsatile Flow, Renal Insufficiency, Chronic, Risk Factors, Time Factors, Vascular Resistance, alpha-2-HS-Glycoprotein
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 07 Sep 2022 13:15
Last Modified: 07 Sep 2022 13:15
URI: http://sro.sussex.ac.uk/id/eprint/107773
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