Ethnic differences in skin microvascular function and their relation to cardiac target-organ damage

Strain, WD, Chaturvedi, N, Leggetter, S, Nihoyannopoulos, P, Rajkumar, C, Bulpitt, CJ and Shore, AC (2005) Ethnic differences in skin microvascular function and their relation to cardiac target-organ damage. Journal of Hypertension, 23 (1). pp. 133-140. ISSN 0263-6352

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Background: People of Black African descent have increased risks of vascular target-organ damage not explained by greater blood pressures. Objective: To study ethnic differences in the microvasculature. Design and methods: Flow (flux) in microcirculatory skin vessels was assessed using laser Doppler fluximetry in 181 Afro-Caribbean and European men and women aged 40-65 years from the general population in London, UK. Flux in response to maximal heating (maximal hyperaemic response) was measured and minimum vascular resistance calculated. Peak flux and time to peak after an ischaemic stimulus were also measured. Target-organ damage was assessed using echocardiographic interventricular septal thickness (IVST). Results: In men, maximum hyperaemic response was attenuated in Afro-Caribbeans [109 arbitrary units (au), 25th and 75th percentiles 101, 117] compared with Europeans [165 (155, 179) au; P = 0.008]. Minimum vascular resistance was greater in Afro-Caribbeans, significantly so in men [(1.22 (1.18, 1.28) au/mmHg compared with 0.80 (0.77, 0.83) au/mmHg; P = 0.006]. Peak ischaemic response was attenuated in Afro-Caribbean men and women compared with Europeans (35.6 au compared with 49.5 au; P < 0.001) and time to peak was prolonged (14.1 s compared with 12.5 s; P = 0.07). These ethnic differences could not be accounted for by standard cardiovascular risk factors. IVST was greater in Afro-Caribbeans than in Europeans. Minimum vascular resistance and peak response accounted for a small proportion of this ethnic difference, in addition to conventional factors. Conclusions: Afro-Caribbeans have poorer microvascular structure and function, unexplained by conventional risk factors, which may contribute to greater rates of vascular target-organ damage. © 2005 Lippincott Williams & Wilkins.

Item Type: Article
Keywords: Adult, Aged, Blacks, Female, Humans, Hypertension, Hypertrophy, Left Ventricular, Ischemia, Laser-Doppler Flowmetry, Male, Microcirculation, Middle Aged, Risk Factors, Skin, Vascular Resistance, Whites
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 07 Sep 2022 14:02
Last Modified: 07 Sep 2022 14:02
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