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Pinto, E, Bulpitt, C, Beckett, N, Peters, R, Staessen, J A and Rajkumar, C (2006) Rationale and methodology of monitoring ambulatory blood pressure and arterial compliance in the Hypertension in the Very Elderly Trial. Blood Pressure Monitoring, 11. pp. 3-8. ISSN 1359-5237
Full text not available from this repository.Abstract
Objective
This article describes the rationale and methodology for the monitoring of ambulatory blood pressure and arterial compliance in hypertensive patients aged 80 years and above. This is a side project of the Hypertension in the Very Elderly Trial.
Methods
The hypertension in the Very Elderly Trial is a multicentre, double-blind, randomized, placebo-controlled trial aiming to investigate the effect of active treatment on cardiovascular and other outcomes in hypertensive patients aged 80 years or more. Patients are randomized to placebo or active treatment starting with the diuretic indapamide and adding the angiotensin-converting enzyme inhibitor perindopril if required. This study has completed a pilot trial and the main trial is now underway. Six hundred patients will have two ABPM recordings, the first at baseline and the second a year after randomization. Arterial compliance is measured using the Q wave (electrocardiogram) to Korotkoff diastole sound interval.
Results
Baseline characteristics for the first 50 patients recruited are presented.
Conclusion
This side project will allow the investigation of 24-h ambulatory measures of blood pressure and arterial compliance as predictors of cerebrovascular and cardiovascular events in the very elderly. The project will also allow the investigation of the blood pressure and vascular compliance profiles in the very elderly and their changes with posture. The association between these measurements and mortality and morbidity in this age group will be addressed.
| Item Type: | Article |
|---|---|
| Keywords: | Aged, 80 and over, Arteries, Blood Pressure, Blood Pressure Monitoring, Ambulatory, Clinical Protocols, Double-Blind Method, Humans, Hypertension, Indapamide, Office Visits, Perindopril |
| Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine |
| SWORD Depositor: | Mx Elements Account |
| Depositing User: | Mx Elements Account |
| Date Deposited: | 08 Sep 2022 09:24 |
| Last Modified: | 08 Sep 2022 09:24 |
| URI: | http://sro.sussex.ac.uk/id/eprint/107763 |