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Ageing and vascular ageing
journal contribution
posted on 2023-06-10, 04:38 authored by B Jani, Chakravarthi RajkumarChakravarthi RajkumarThere is an age related decline in various physiological processes. Vascular ageing is associated with changes in the mechanical and the structural properties of the vascular wall, which leads to the loss of arterial elasticity and reduced arterial compliance. Arterial compliance can be measured by different parameters like pulse wave velocity, augmentation index, and systemic arterial compliance. There is evidence that arterial compliance is reduced in disease states such as hypertension, diabetes, and end stage renal failure. Changes in arterial compliance can be present before the clinical manifestation of cardiovascular disease. Pharmacological and non-pharmacological measures have been shown to improve arterial compliance. Arterial compliance may constitute an early cardiovascular risk marker and may be useful in assessing the effects of drugs on the cardiovascular system. Pharmacogenetics and genetics of arterial compliance in the future will improve our knowledge and understanding about vascular ageing.
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Publication status
- Published
Journal
Postgraduate Medical JournalISSN
0032-5473Publisher
BMJExternal DOI
Volume
82Page range
357-362Event location
EnglandDepartment affiliated with
- Clinical and Experimental Medicine Publications
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- No
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2022-09-08Usage metrics
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