Jani, B and Rajkumar, C (2006) Ageing and vascular ageing. Postgraduate Medical Journal, 82. pp. 357-362. ISSN 0032-5473

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Abstract

There is an age related decline in various physiological processes. Vascular ageing is associated with changes in the mechanical and the structural properties of the vascular wall, which leads to the loss of arterial elasticity and reduced arterial compliance. Arterial compliance can be measured by different parameters like pulse wave velocity, augmentation index, and systemic arterial compliance. There is evidence that arterial compliance is reduced in disease states such as hypertension, diabetes, and end stage renal failure. Changes in arterial compliance can be present before the clinical manifestation of cardiovascular disease. Pharmacological and non-pharmacological measures have been shown to improve arterial compliance. Arterial compliance may constitute an early cardiovascular risk marker and may be useful in assessing the effects of drugs on the cardiovascular system. Pharmacogenetics and genetics of arterial compliance in the future will improve our knowledge and understanding about vascular ageing.

Item Type:	Article
Keywords:	Aging, Arteries, Blood Flow Velocity, Blood Pressure, Cardiovascular Diseases, Cardiovascular Physiological Phenomena, Compliance, Diet, Elasticity, Exercise, Forecasting, Genotype, Hormone Replacement Therapy, Humans, Risk Factors, Sex Characteristics, Smoking
Schools and Departments:	Brighton and Sussex Medical School > Clinical and Experimental Medicine
SWORD Depositor:	Mx Elements Account
Depositing User:	Mx Elements Account
Date Deposited:	08 Sep 2022 09:32
Last Modified:	08 Sep 2022 09:32
URI:	http://sro.sussex.ac.uk/id/eprint/107761

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