The relationship between androgens and arterial stiffness in older men

Dockery, F, Bulpitt, C J, Donaldson, M, Fernandez, S and Rajkumar, C (2003) The relationship between androgens and arterial stiffness in older men. Journal of the American Geriatrics Society, 51 (11). pp. 1627-1632. ISSN 0002-8614

Full text not available from this repository.


Objectives: To assess the relationship between endogenous androgen levels and arterial stiffness in older men.

Design: A retrospective, cross-sectional study.

Setting: A London hospital-based, clinical research unit for the elderly.

Participants: Fifty-five men (mean age±standard deviation=71.1±8.0).

Intervention: Sex hormone-binding globulin (SHBG), testosterone, and dehydroepiandrosterone sulfate (DHEAS) were measured in all subjects who had a stored serum sample drawn the same day as arterial stiffness measures were performed. Free testosterone index (FTI) was calculated ((total testosterone/SHBG)×100 (%)). The measures of arterial stiffness used were pulse wave velocity (PWV) using the Complior system and systemic arterial compliance (SAC) using the area method.

Measurements: Relationship between arterial stiffness and serum androgens.

Results: FTI showed a strong positive relationship with SAC (r=0.507, P<.001) and, correspondingly, an inverse relationship with carotid-femoral (C-F) and carotid-radial (C-R) PWV (r=–0.427 and –0.402, respectively, P≤.002). With multiple regression, including age, blood pressure, cholesterol, body mass index, and waist/hip ratio, FTI remained a significant determinant of SAC and C-R PWV but not C-F PWV. In the subgroup of men without cardiovascular disease or vasoactive medication use (n=37), all three relationships remained significant. DHEAS was inversely related to C-F PWV only (r=–0.304, P=.041).

Conclusion: The known association between lower androgenicity and increased cardiovascular risk in men might be explained by altered vascular stiffness.

Item Type: Article
Keywords: Aged, Algorithms, Androgens, Blood Pressure, Blood Pressure Determination, Cardiovascular Diseases, Compliance, Cross-Sectional Studies, Dehydroepiandrosterone Sulfate, Humans, Hypertension, Linear Models, Male, Middle Aged, Retrospective Studies, Stroke Volume, Testosterone, Vascular Resistance
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 08 Sep 2022 09:00
Last Modified: 08 Sep 2022 09:00
📧 Request an update