Immune response to a single bout of exercise in young and elderly subjects

Mazzeo, RS, Rajkumar, C, Rolland, J, Blaher, B, Jennings, G and Esler, M (1998) Immune response to a single bout of exercise in young and elderly subjects. Mechanisms of Ageing and Development, 100 (2). pp. 121-132. ISSN 0047-6374

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The purpose of this investigation was to examine alterations in lymphocyte proliferation activity and T cell subsets following an acute bout of exercise in young and old subjects. Six young (26 ± 3 years) and nine old (69 ± 5 years) male subjects were tested at rest and immediately after 20 min of submaximal exercise at 50% peak work capacity. Arterial blood was sampled from an indwelling catheter for catecholamine and immunology assays. Peripheral blood lymphocytes were isolated for mitogen-induced phytohemagglutinin (PHA) proliferation capacity. Lymphocyte subsets were analyzed by dual-labeled flow cytometry. As has been shown in previous studies, baseline proliferative responsiveness was significantly lower in the old (↓ 22%) compared to the young subjects. In response to submaximal exercise, proliferative responsiveness to PHA increased significantly in the young subjects (↑ 55%), however, for the old subjects this response did not differ significantly from resting values (↑ 18%). The number of total lymphocytes, as well as CD4+ and CD8+ T cell subsets, at rest were lower for old subjects compared with young. Exercise-induced increases in T cell subset populations were similar across age groups. It was concluded that, while having lower initial T cell numbers and PHA responsiveness, immunoresponsiveness during a single bout of exercise is, in general, maintained in old when compared to young individuals.

Item Type: Article
Keywords: Adult, Aged, Aging, Cell Division, Epinephrine, Exercise, Heart Rate, Humans, Leukocyte Count, Lymphocyte Subsets Male, Norepinephrine
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 07 Sep 2022 14:23
Last Modified: 07 Sep 2022 14:23
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