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Immune response to a single bout of exercise in young and elderly subjects
journal contribution
posted on 2023-06-10, 04:38 authored by RS Mazzeo, Chakravarthi RajkumarChakravarthi Rajkumar, J Rolland, B Blaher, G Jennings, M EslerThe purpose of this investigation was to examine alterations in lymphocyte proliferation activity and T cell subsets following an acute bout of exercise in young and old subjects. Six young (26 ± 3 years) and nine old (69 ± 5 years) male subjects were tested at rest and immediately after 20 min of submaximal exercise at 50% peak work capacity. Arterial blood was sampled from an indwelling catheter for catecholamine and immunology assays. Peripheral blood lymphocytes were isolated for mitogen-induced phytohemagglutinin (PHA) proliferation capacity. Lymphocyte subsets were analyzed by dual-labeled flow cytometry. As has been shown in previous studies, baseline proliferative responsiveness was significantly lower in the old (? 22%) compared to the young subjects. In response to submaximal exercise, proliferative responsiveness to PHA increased significantly in the young subjects (? 55%), however, for the old subjects this response did not differ significantly from resting values (? 18%). The number of total lymphocytes, as well as CD4+ and CD8+ T cell subsets, at rest were lower for old subjects compared with young. Exercise-induced increases in T cell subset populations were similar across age groups. It was concluded that, while having lower initial T cell numbers and PHA responsiveness, immunoresponsiveness during a single bout of exercise is, in general, maintained in old when compared to young individuals.
History
Publication status
- Published
Journal
Mechanisms of Ageing and DevelopmentISSN
0047-6374Publisher
Elsevier BVExternal DOI
Issue
2Volume
100Page range
121-132Event location
IrelandDepartment affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2022-09-07Usage metrics
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