Vascular compliance as a measure of biological age

Bulpitt, C J, Rajkumar, C and Cameron, J D (2015) Vascular compliance as a measure of biological age. Journal of the American Geriatrics Society, 47 (6). pp. 657-663. ISSN 0002-8614

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To determine the measure of vascular compliance most closely related to age.

A review of 22 studies relating aortic compliance to age and a discussion of other factors related to vascular compliance.

Aortic compliance, elastic modulus, postmortem aortic changes, pulse wave velocity in the aorta, common carotid, lower limb and upper limb.

1. Aortic compliance and carotid artery compliance is closely related to age; 2. Compliance in the peripheral arteries, in 16 reports, appears less closely related to age; 3. There is evidence that aortic compliance is related to hypertension, cardiac function, and left ventricular hypertrophy and can be increased by exercise, hormonal therapy, antioxidant and antihypertensive treatment; and 4. Vascular compliance is more closely related to chronological age than other measures such as skin inelasticity, greying of hair, baldness etc.

Because of the close relationship between aortic and carotid compliance and chronological age, deviation from the age-predicted norm (biological age) may prove to be a good predictor of cardiovascular pathology. J Am Geriatr Soc 47:657–663, 1999.

Item Type: Article
Keywords: Aging, Arteries, Blood Flow Velocity, Compliance, Humans, Pulse, Vascular Capacitance
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 08 Sep 2022 09:22
Last Modified: 08 Sep 2022 09:22
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