Covid-19 effects on ARTErial StIffness and vascular AgeiNg: CARTESIAN study rationale and protocol

Bruno, Rosa M, Spronck, Bart, Hametner, Bernhard, Hughes, Alun, Lacolley, Patrick, Mayer, Christopher C, Muiesan, Maria L, Rajkumar, Chakravarthi, Terentes-Printzios, Dimitrios, Weber, Thomas, Hansen, Tine W, Boutouyrie, Pierre and ARTERY Society, (2021) Covid-19 effects on ARTErial StIffness and vascular AgeiNg: CARTESIAN study rationale and protocol. Artery Research, 27 (2). pp. 59-68. ISSN 1872-9312

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In December 2019, an outbreak of pneumonia caused by a novel Coronavirus (COVID-19) spread rapidly worldwide. Although the clinical manifestations of COVID-19 are dominated by respiratory symptoms, the cardiovascular system is extensively affected at multiple levels. Due to the unprecedented consequences of the COVID-19 pandemic, the ARTERY society decided to launch the Covid-19 effects on ARTErial StIffness and vascular AgeiNg (CARTESIAN) study — the first international multicentre study into the effects of COVID-19 on non-invasive biomarkers of vascular ageing. The main study objective is to evaluate the presence of Early Vascular Ageing (EVA) 6 and 12 months after COVID-19 infection. Secondary objectives are to study the effect of COVID-19 disease severity on EVA, to investigate the role of psychosocial factors in COVID-19 induced EVA, and to investigate the potential modifying effect of comorbidities and chronic treatments. In the CARTESIAN study, a broad array of cardiovascular measurements, including carotid-femoral pulse wave velocity, central blood pressure, carotid ultrasound, brachial flow-mediated dilatation, will be performed. To date, 43 centres from 21 countries have agreed to participate, with an expected study population of >2500 individuals. To our knowledge, CARTESIAN will be the first study to provide insight into the relationship between COVID-19, its severity, and early vascular ageing in a large cohort, potentially enabling future care and diagnostics to be more focused on the most vulnerable.

Item Type: Article
Keywords: COVID-19, arterial stiffness, coronavirus, inflammation, vascular ageing
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 08 Sep 2022 10:29
Last Modified: 09 Sep 2022 09:00

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