Prognostic Value of Immunohistochemical Markers for Locally Advanced Rectal Cancer. .pdf (2.38 MB)
Prognostic value of immunohistochemical markers for locally advanced rectal cancer
journal contribution
posted on 2023-06-10, 04:34 authored by Anas Taha, Stephanie Taha-Mehlitz, Stephanie Petzold, Sergey L Achinovich, Dmitry Zinovkin, Bassey Enodien, Md Zahidul I Pranjol, Eldar A NadyrovThe aim of this study is to reveal the potential roles of apoptosis markers (Bcl2 and p53), proliferation markers (Ki-67 and CyclD1), and the neuroendocrine marker Chromogranin A as markers for the radioresistance of rectal cancer. Statistically significant differences were found in the expression of p53, Ki-67, and Chromogranin A in groups of patients with and without a favorable prognosis after radiotherapy. The survival analysis revealed that the marker of neuroendocrine differentiation, Chromogranin A, also demonstrated a high prognostic significance, indicating a poor prognosis. Markers of proliferation and apoptosis had no prognostic value for patients who received preoperative radiotherapy. Higher Chromogranin A values were predictors of poor prognosis. The results obtained from studying the Chromogranin A expression suggest that the secretion of biologically active substances by neuroendocrine cells causes an increase in tumor aggressiveness.
History
Publication status
- Published
File Version
- Published version
Journal
MoleculesISSN
1420-3049Publisher
MDPIExternal DOI
Issue
3Volume
27Page range
596 1-9Event location
SwitzerlandDepartment affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-09-02First Open Access (FOA) Date
2022-09-02First Compliant Deposit (FCD) Date
2022-09-02Usage metrics
Categories
No categories selectedKeywords
Chromogranin Aapoptosisproliferationradiotherapyrectal cancerAdenocarcinomaAdultAgedBiomarkersTumorCyclin D1FemaleFollow-Up StudiesHumansImmunohistochemistryKi-67 AntigenMaleMiddle AgedNeuroendocrine CellsPrognosisProto-Oncogene Proteins c-bcl-2Rectal NeoplasmsSurvival RateTumor Suppressor Protein p53
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC