fimmu-13-976677.pdf (3.42 MB)
The mechanistic immunosuppressive role of the tumour vasculature and potential nanoparticle-mediated therapeutic strategies
journal contribution
posted on 2023-06-10, 04:34 authored by Zaharia E Ileiwat, Tanveer Tabish, Dmitry Zinovkin, Jale Yuzugulen, Nahid Arghiani, Zahid PranjolThe tumour vasculature is well-established to display irregular structure and hierarchy that is conducive to promoting tumour growth and metastasis while maintaining immunosuppression. As tumours grow, their metabolic rate increases while their distance from blood vessels furthers, generating a hypoxic and acidic tumour microenvironment. Consequently, cancer cells upregulate the expression of pro-angiogenic factors which propagate aberrant blood vessel formation. This generates atypical vascular features that reduce chemotherapy, radiotherapy, and immunotherapy efficacy. Therefore, the development of therapies aiming to restore the vasculature to a functional state remains a necessary research target. Many anti-angiogenic therapies aim to target this such as bevacizumab or sunitinib but have shown variable efficacy in solid tumours due to intrinsic or acquired resistance. Therefore, novel therapeutic strategies such as combination therapies and nanotechnology-mediated therapies may provide alternatives to overcoming the barriers generated by the tumour vasculature. This review summarises the mechanisms that induce abnormal tumour angiogenesis and how the vasculature’s features elicit immunosuppression. Furthermore, the review explores examples of treatment regiments that target the tumour vasculature.
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Publication status
- Published
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- Published version
Journal
Frontiers in ImmunologyISSN
1664-3224Publisher
Frontiers MediaExternal DOI
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1-16Department affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-09-02First Open Access (FOA) Date
2022-09-02First Compliant Deposit (FCD) Date
2022-09-01Usage metrics
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