Using genetic designs to identify likely causal environmental contributions to psychopathology

Sellers, Ruth, Riglin, Lucy, Harold, Gordon and Thapar, Anita (2022) Using genetic designs to identify likely causal environmental contributions to psychopathology. Development and Psychopathology. pp. 1-13. ISSN 0954-5794

[img] PDF - Accepted Version
Restricted to SRO admin only until 7 April 2023.

Download (513kB)

Abstract

The multifactorial nature of psychopathology, whereby both genetic and environmental factors contribute risk, has long been established. In this paper, we provide an update on genetically informative designs that are utilized to disentangle genetic and environmental contributions to psychopathology. We provide a brief reminder of quantitative behavioral genetic research designs that have been used to identify potentially causal environmental processes, accounting for genetic contributions. We also provide an overview of recent molecular genetic approaches that utilize genome-wide association study data which are increasingly being applied to questions relevant to psychopathology research. While genetically informative designs typically have been applied to investigate the origins of psychopathology, we highlight how these approaches can also be used to elucidate potential causal environmental processes that contribute to developmental course and outcomes. We highlight the need to use genetically sensitive designs that align with intervention and prevention science efforts, by considering strengths-based environments to investigate how positive environments can mitigate risk and promote children’s strengths.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Primary Care and Public Health
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 01 Sep 2022 08:44
Last Modified: 02 Nov 2022 11:00
URI: http://sro.sussex.ac.uk/id/eprint/107642

View download statistics for this item

📧 Request an update