Ruffles, Tom, Basu, Kaninika, Inglis, Sarah K, Bremner, Stephen, Rabe, Heike, Memon, Anjum, Seddon, Paul, Tavendale, Roger, Palmer, Colin N A, Mukhopadhyay, Somnath and Fidler, Katy (2022) Mannose-binding lectin genotype is associated with respiratory disease in young children: a multi-centre cohort study. Pediatr Pulmonol. pp. 1-25. ISSN 8755-6863

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Abstract

Background
Mannose binding lectin (MBL) is an important component of the innate immune system. Polymorphisms in the MBL2 gene and promoter region are directly associated with MBL-deficiency. We sought to determine the association between MBL genotype on the frequency of common childhood respiratory infections, respiratory symptoms, and atopic outcomes in early childhood.

Methods
MBL2 gene variants were analysed in newborns recruited to the GO-CHILD multi-centre prospective cohort study. Follow-up for respiratory infection and atopy diagnoses and symptoms, healthcare utilisation and medication prescription were conducted by postal questionnaires at 12 and 24-months.

Results
Genotyping and follow-up were completed in 1004 children. Genotypes associated with MBL-deficiency were associated with an increased risk of bronchiolitis (relative risk (RR) 1.95, 95%CI 1.33-2.85)) and pneumonia (RR 2.46, 95%CI 1.16-5.22). MBL-deficient genotypes were associated with an increased risk of wheeze with shortness of breath episodes (RR 1.22, 95%CI 1.04-1.43), emergency department attendance (RR 1.90 95%CI 1.13-3.19) and hospital admission (RR 2.01, 95%CI 1.04-3.89) for wheeze. MBL-deficient genotypes were associated with a reduced risk of developing atopic dermatitis (RR 0.72, 95%CI 0.53-0.98).

Conclusion
The positive association between MBL-deficient genotypes and bronchiolitis and pneumonia, as well as a severe wheeze phenotype in some young children, supports the hypothesis that MBL is an important component of innate immunity in the vulnerable period prior to the maturation of the adaptive immune system. Identification of disease modifying genotypes may help target preventative strategies in high-risk infants. This article is protected by copyright. All rights reserved.

Item Type:	Article
Keywords:	Bronchiolitis, Mannose-binding lectin, Pneumonia & Dermatitis, Respiratory tract infections, atopic
Schools and Departments:	Brighton and Sussex Medical School > Primary Care and Public Health
SWORD Depositor:	Mx Elements Account
Depositing User:	Mx Elements Account
Date Deposited:	18 Aug 2022 09:35
Last Modified:	12 Sep 2022 12:48
URI:	http://sro.sussex.ac.uk/id/eprint/107451

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