Association of a genetic variant in the ATP-binding cassette sub-family B member 1 with risk of cervical cancer

Armanpur, Samira, Malekzade, Sara and Ferns, Gordon (2022) Association of a genetic variant in the ATP-binding cassette sub-family B member 1 with risk of cervical cancer. Human Gene, 34. a201097 1-4. ISSN 2773-0441

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Abstract

Background
Cervical cancer is one of the most prevalent cancers among women and is associated with high morbidity and mortality. Several factors are involved in the pathogenesis of cervical cancer including viral infections and/or genetic modifications that include single nucleotide polymorphisms (SNPs).

Methods
We aimed to investigate the association of genetic variants in ATP Binding Cassette Subfamily B Member 1 (ABCB1) (rs1128503) and Fc Gamma Receptor IIIa (FCGR3A) (rs396991) genes and susceptibility to cervical cancer in 263 individuals with or without this form of cancer. DNA samples were isolated and genotyped using a TaqMan based real-time (RT-) PCR method.

Results
The rs1128503 was found to be associated with an increased risk of cervical cancer (recessive model: OR=2.6, CI: 1.1-5.8, p=0.02). whilst there was no association between the rs396991 and susceptibility to cervical cancer.

Conclusion
Our results showed that there is an association between the ABCB1 polymorphism and susceptibility for cervical cancer suggesting its potential as a risk stratification marker for cervical neoplasia.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 10 Aug 2022 10:49
Last Modified: 23 Sep 2022 11:45
URI: http://sro.sussex.ac.uk/id/eprint/107333

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