Force estimation - A Madzvamuse 15.07.22.pdf (13.39 MB)
Force estimation during cell migration using mathematical modelling
journal contribution
posted on 2023-06-10, 04:19 authored by Fengwei Yang, Chandrasekhar VenkataramanChandrasekhar Venkataraman, Sai Gu, Vanessa StylesVanessa Styles, Anotida MadzvamuseCell migration is essential for physiological, pathological and biomedical processes such as, in embryogenesis, wound healing, immune response, cancer metastasis, tumour invasion and inflammation. In light of this, quantifying mechanical properties during the process of cell migration is of great interest in experimental sciences, yet few theoretical approaches in this direction have been studied. In this work, we propose a theoretical and computational approach based on the optimal control of geometric partial differential equations to estimate cell membrane forces associated with cell polarisation during migration. Specifically, cell membrane forces are inferred or estimated by fitting a mathematical model to a sequence of images, allowing us to capture dynamics of the cell migration. Our approach offers a robust and accurate framework to compute geometric mechanical membrane forces associated with cell polarisation during migration and also yields geometric information of independent interest, we illustrate one such example that involves quantifying cell proliferation levels which are associated with cell division, cell fusion or cell death.
History
Publication status
- Published
File Version
- Published version
Journal
Journal of ImagingISSN
2313-433XPublisher
MDPI AGExternal DOI
Issue
7Volume
8Page range
199-199Department affiliated with
- Mathematics Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-07-26First Open Access (FOA) Date
2022-07-26First Compliant Deposit (FCD) Date
2022-07-25Usage metrics
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