Clinical Laboratory Analysis - 2022 - Zafari - The role of the tumor microenvironment in colorectal cancer and the.pdf (1.93 MB)
The role of the tumour microenvironment in colorectal cancer and the potential therapeutic approaches
journal contribution
posted on 2023-06-10, 04:09 authored by Gordon FernsGordon Ferns, Narges Zafari, Fatemeh Khosravi, Zahra Razaee, Sahar Esfandyari, Mohamad Bahiraei, Afshin Bahramy, Amir AvanColorectal cancer (CRC) with a high prevalence is recognized as the fourth most common cause of cancer related death globally. Over the past decade, there has been growing interest in the network of tumor cells, stromal cells, immune cells, blood vessel cells, and fibroblasts that comprise the tumor microenvironment (TME) to identify new therapeutic interventions. TME as a result of the crosstalk between these cells may result in either advantages or disadvantages in tumor development and metastasis, affecting the signals and responses from the surrounding cells. Whilst chemotherapy has led to an improvement in CRC patients’ survival, the metastatic aspect of the disease remains difficult to avoid. Therefore, the present review emphasizes the structure and function of the TME, alterations in the TME, its role in the incidence and progression of CRC, the effects on tumor development and metastasis, and also the potential of its alterations as therapeutic targets. It should be noted that providing novel studies in this field of research might help us to achieve practical therapeutic strategies based on their interaction.
History
Publication status
- Published
File Version
- Published version
Journal
Journal of Clinical and Laboratory AnalysisISSN
0887-8013Publisher
WileyExternal DOI
Page range
1-17Department affiliated with
- Division of Medical Education Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-07-01First Open Access (FOA) Date
2022-08-18First Compliant Deposit (FCD) Date
2022-07-01Usage metrics
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