The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study

Mirinezhad, Mohammad Reza, Ghazizadeh, Hamideh, Aghsizadeh, Maliheh, Zamiri Bidary, Mohammad, Naghipour, Alireza, Hasanzadeh, Elahe, Yaghooti-Khorasani, Mahdiyeh, Ebrahimi Dabagh, Ali, Moghadam, Mohammad Reza Shadmand Foumani, Sheikh Andalibi, Nazzanin, Naseri Far, Zeynab, Esmaily, Habibollah, Ferns, Gordon A, Hamzehloei, Tayebeh, Pasdar, Alireza and Ghayour-Mobarhan, Majid (2022) The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study. BMC Women's Health, 22. p. 2. ISSN 1472-6874

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Abstract

Background and aim: Primary Ovarian Insufficiency (POI) is defined by the occurrence of menopause before the age of 40 years. It is often associated with cardiovascular disease (CVD). The purpose of this study was to explore the relationship between POI-associated genotypes cardiometabolic disorder risk factors. Methods: One hundred seventeen women with POI and one hundred eighty-three healthy women without POI were recruited in this study. DNA was extracted and analyzed using ASO-PCR or Tetra ARMS-PCR. Lipid profiles were also assessed. Results: Multivariate logistic regression analysis showed that individuals with GG vs. TT genotype of the rs1046089 SNP were more likely to have a higher serum LDL (p = 0.03) compared to the control group. There was also a significant association between low serum HDL and rs2303369 and rs4806660 SNP genotypes in the POI group. In the POI group, the percentage of those with high total cholesterol was lower in those with a CC genotype compared to those with a TT genotype (p = 0.03). Conclusion: Some SNPs reported to be associated with POI appear to be independently associated with dyslipidemia. These results may be helpful to identify subjects with POI who may be susceptible to CVD.

Item Type: Article
Keywords: ARMS-PCR;ASO-PCR;Cardiovascular disease;Primary Ovarian Insufficiency;Adult;Cardiovascular Diseases;Cohort Studies;Female;Humans;Lipids;Polymorphism, Single Nucleotide;Primary Ovarian Insufficiency
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 04 Jul 2022 08:56
Last Modified: 04 Jul 2022 09:00
URI: http://sro.sussex.ac.uk/id/eprint/106735

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