accepted trach change ALD revised.pdf (819.14 kB)
Role of gut bacterial and non-bacterial microbiota in alcohol-associated liver disease: Molecular mechanisms, biomarkers and therapeutic prospective
journal contribution
posted on 2023-06-10, 04:08 authored by Nima Zafari, Mahla Velayati, Mostafa Fahim, Mina Maftooh, Ghazaleh Pourali, Majid Khazaei, Mohammadadreza Nassiri, Seyed Mahdi Hassanian, Majid Ghayour-Mobarhan, Gordon FernsGordon Ferns, Mohammed Ali Kiani, Amir AvianAlcohol-associated liver disease (ALD) comprises a spectrum of liver diseases that include: steatosis to alcohol-associated hepatitis, cirrhosis, and ultimately hepatocellular carcinoma. The pathophysiology and potential underlying mechanisms for alcohol-associated liver disease are unclear. Moreover, the treatment of ALD remains a challenge. Intestinal microbiota include bacteria, fungi, and viruses, that are now known to be important in the development of ALD. Alcohol consumption can change the gut microbiota and function leading to liver disease. Given the importance of interactions between intestinal microbiota, alcohol, and liver injury, the gut microbiota has emerged as a potential biomarker and therapeutic target. This review focuses on the potential mechanisms by which the gut microbiota may be involved in the pathogenesis of ALD and explains how this can be translated into clinical management. We discuss the potential of utilizing the gut microbiota signature as a biomarker in ALD patients. Additionally, we present an overview of the prospect of modulating the intestinal microbiota for the management of ALD.
History
Publication status
- Published
File Version
- Accepted version
Journal
Life SciencesISSN
0024-3205Publisher
ElsevierExternal DOI
Volume
305Page range
1-14Department affiliated with
- Division of Medical Education Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2022-07-04First Compliant Deposit (FCD) Date
2022-07-01Usage metrics
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