Role of gut bacterial and non-bacterial microbiota in alcohol-associated liver disease: Molecular mechanisms, biomarkers and therapeutic prospective

Zafari, Nima, Velayati, Mahla, Fahim, Mostafa, Maftooh, Mina, Pourali, Ghazaleh, Khazaei, Majid, Nassiri, Mohammadadreza, Hassanian, Seyed Mahdi, Ghayour-Mobarhan, Majid, Ferns, Gordon A, Kiani, Mohammed Ali and Avian, Amir (2022) Role of gut bacterial and non-bacterial microbiota in alcohol-associated liver disease: Molecular mechanisms, biomarkers and therapeutic prospective. Life Sciences, 305. pp. 1-14. ISSN 0024-3205

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Abstract

Alcohol-associated liver disease (ALD) comprises a spectrum of liver diseases that include: steatosis to alcohol-associated hepatitis, cirrhosis, and ultimately hepatocellular carcinoma. The pathophysiology and potential underlying mechanisms for alcohol-associated liver disease are unclear. Moreover, the treatment of ALD remains a challenge. Intestinal microbiota include bacteria, fungi, and viruses, that are now known to be important in the development of ALD. Alcohol consumption can change the gut microbiota and function leading to liver disease. Given the importance of interactions between intestinal microbiota, alcohol, and liver injury, the gut microbiota has emerged as a potential biomarker and therapeutic target. This review focuses on the potential mechanisms by which the gut microbiota may be involved in the pathogenesis of ALD and explains how this can be translated into clinical management. We discuss the potential of utilizing the gut microbiota signature as a biomarker in ALD patients. Additionally, we present an overview of the prospect of modulating the intestinal microbiota for the management of ALD.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 04 Jul 2022 08:35
Last Modified: 18 Aug 2022 13:30
URI: http://sro.sussex.ac.uk/id/eprint/106734

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