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Thrombocytopenia: the good, the bad and the ugly

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posted on 2023-06-10, 04:01 authored by Iona Ashworth, Lieze Thielemans, Timothy ChevassutTimothy Chevassut
New thrombocytopenia may be associated with a variety of conditions and diagnosis can be challenging. Presentation can vary from life-threatening bleeding or thrombosis to an incidental finding in an asymptomatic patient. New thrombocytopenia requires urgent investigation. Investigations are mainly guided by findings from the clinical history, physical examination, full blood count and blood film analysis. Aside from the actively bleeding patient, rare but life-threatening causes of thrombocytopenia must be identified early as they require urgent treatment. These include thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, suspicion of new acute promyelocytic leukaemia, and vaccine-induced prothrombotic immune thrombocytopenia. Here, we discuss how to approach a patient with new thrombocytopenia, along with key differentials not to be missed.

History

Publication status

  • Published

File Version

  • Published version

Journal

Clinical Medicine Journal

ISSN

1470-2118

Publisher

Royal College of Physicians

Issue

3

Volume

22

Page range

214-217

Event location

England

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2022-06-23

First Open Access (FOA) Date

2022-06-23

First Compliant Deposit (FCD) Date

2022-06-23

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