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Lymphocytosis and chronic lymphocytic leukaemia: investigation and management
journal contribution
posted on 2023-06-10, 04:01 authored by Amarpreet Devi, Lieze Thielemans, Eleni Ladikou, Taran K Nandra, Timothy ChevassutTimothy ChevassutLymphocytosis is a common blood-test finding. Establishing whether the cause of lymphocytosis is benign or malignant is key to managing patients appropriately. A lymphocytosis should always prompt clinical review including a thorough history, examination and appropriate preliminary investigations (blood tests, blood film). The majority of patients with chronic lymphocytic leukaemia (CLL) present incidentally due to a lymphocytosis found on routine blood tests. Patient outcomes vary considerably based on genetic pre-disposition and various prognostic markers (age, Binet or Rai staging, and B2-microglobulin). Although not curative, chemo-immunotherapy is an effective treatment strategy for the majority of CLL patients with progressive disease. More recently, novel oral therapies have been developed that target key signalling and apoptosis pathways and that are being used in relapse settings and as first-line treatments for certain patients.
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Publication status
- Published
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- Published version
Journal
Clinical Medicine JournalISSN
1470-2118Publisher
Royal College of PhysiciansExternal DOI
Volume
22Page range
225-229Event location
EnglandDepartment affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-06-23First Open Access (FOA) Date
2022-06-23First Compliant Deposit (FCD) Date
2022-06-23Usage metrics
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