catalysts-12-00660-v2.pdf (17.21 MB)
Metal-catalysed A3 coupling methodologies: classification and visualisation
journal contribution
posted on 2023-06-10, 03:59 authored by Jonathan Farhi, Ioannis N Lykakis, George KostakisGeorge KostakisThe multicomponent reaction of aldehydes, amines, and alkynes, known as A3 coupling, yields propargylamines, a valuable organic scaffold, and has received significant interest and attention in the last years. In order to fully realise the potential of the metal-based catalytic protocols that facilitate this transformation, we summarise substrates, in situ and well-characterised synthetic methods that provide this scaffold and attempt a monumental classification considering several variables (Metal, Coordinating atom(s), Ligand type and name, in-situ or well-characterised, co-catalyst, catalyst and ligand Loading (mol%), solvent, volume, atmosphere, temperature, microwave, time, yield, selectivity (e.e. d.r.), substrate name, functionality, loading (amines, aldehydes, alkynes), and use of molecular sieves). This pioneering work creates a valuable database that contains 2376 entries and allows us to produce graphs and better visualise their impact on the reaction.
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- Published
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- Published version
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CatalystsISSN
2073-4344Publisher
MDPI AGExternal DOI
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6Volume
12Page range
660-660Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-06-19First Open Access (FOA) Date
2022-06-15First Compliant Deposit (FCD) Date
2022-06-19Usage metrics
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