The prevalence and incidence of Irritable Bowel Syndrome and Inflammatory Bowel Disease in depression and bipolar disorder: a systematic review and meta-analysis

Nikolova, Viktoriya L, Pelton, Lucy, Moulton, Calum D, Zorzato, Daniele, Cleare, Anthony J, Young, Allan H and Stone, James (2022) The prevalence and incidence of Irritable Bowel Syndrome and Inflammatory Bowel Disease in depression and bipolar disorder: a systematic review and meta-analysis. Psychosomatic Medicine, 84 (3). pp. 313-324. ISSN 0033-3174

[img] PDF - Accepted Version
Restricted to SRO admin only until 25 January 2023.
Available under License Creative Commons Attribution-Non-Commercial.

Download (823kB)

Abstract

Objective: The increased prevalence and incidence of affective disorders among patients with gastrointestinal disease have been well established. However, few studies have investigated the inverse relationship. We aimed to identify all pieces of evidence of the prevalence and incidence of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) in people with depression and bipolar disorder.

Methods: We conducted a systematic review of studies reporting the association between affective disorders (exposure) and IBS or IBD (outcome) in adults. Evidence was evaluated for quality using Joanna Briggs Institute Critical Appraisal tools. Where suitable data were available, meta-analyses were performed.

Results: We identified 18 studies that met the selection criteria, of which 11 provided data on IBS, 5 on IBD, and 2 on both. Overall, people with depression were significantly more likely to have comorbid IBS (risk ratio = 2.42, 95% confidence interval = 1.98-2.96) and to develop new-onset IBS (risk ratio = 1.90, 95% confidence interval = 1.41-2.56) compared with people without depression. They were also more likely to have and develop IBD, and among patients with IBD, significantly increased rates of depression were observed as early as 5 years before diagnosis. Bipolar disorder was not consistently associated with risk of either condition.

Conclusions: People with depression are at an increased risk of both having and developing lower gastrointestinal disorders. These findings have important implications for how we understand, manage, and prevent this comorbidity in clinical practice. Further studies are needed to improve our understanding of the relationship between bipolar disorder and bowel disease as well as the role of psychotropic medication, particularly selective serotonin reuptake inhibitors.

Item Type: Article
Keywords: Adult, Bipolar Disorder, Depression, Humans, Incidence, Inflammatory Bowel Diseases, Irritable Bowel Syndrome, Prevalence
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 20 Jun 2022 19:16
Last Modified: 22 Jun 2022 07:02
URI: http://sro.sussex.ac.uk/id/eprint/106468

View download statistics for this item

📧 Request an update