Diseases, disorders, and comorbidities of interoception

Bonaz, Bruno, Lane, Richard D, Oshinsky, Michael L, Kenny, Paul J, Sinha, Rajita, Mayer, Emeran A and Critchley, Hugo D (2021) Diseases, disorders, and comorbidities of interoception. Trends in Neurosciences, 44 (1). pp. 39-51. ISSN 0166-2236

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Interoception, the sense of the body's internal physiological state, underpins homeostatic reflexes, motivational states, and sensations contributing to emotional experiences. The continuous nature of interoceptive processing, coupled to behavior, is implicated in the neurobiological construction of the sense of self. Aberrant integration and control of interoceptive signals, originating in the brain and/or the periphery, can perturb the whole system. Interoceptive abnormalities are implicated in the pathophysiology of psychiatric disorders and in the symptomatic expression of developmental, neurodegenerative, and neurological disorders. Moreover, interoceptive mechanisms appear central to somatic disorders of brain–body interactions, including functional digestive disorders, chronic pain, and comorbid conditions. The present article provides an overview of disorders of interoception and suggests future directions for better understanding, diagnosis, and management of these disorders.

Item Type: Article
Keywords: chronic pain, interoception, irritable bowel syndrome, neurological disorders, pelvic disorders, psychiatric disorders, Brain, Chronic Pain, Emotions, Humans, Interoception, Mental Disorders
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 15 Jun 2022 12:54
Last Modified: 09 Sep 2022 10:57
URI: http://sro.sussex.ac.uk/id/eprint/106402

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