ENIGMA-anxiety working group Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.pdf (1.66 MB)
ENIGMA-anxiety working group: rationale for and organization of large-scale neuroimaging studies of anxiety disorders
journal contribution
posted on 2023-06-10, 03:53 authored by Janna Marie Bas-Hoogendam, Nynke A Groenewold, Moji Aghajani, Gabrielle F Freitag, Anita Harrewijn, Kevin Hilbert, Neda Jahanshad, Sophia I Thomopoulos, Paul M Thompson, Dick J Veltman, Anderson M Winkler, Ulrike Lueken, Daniel S Pine, Hugo CritchleyHugo Critchley, Frances Meeten, Matteo Mancini, The ENIGMA-Anxiety Working GroupAnxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA-Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. This paper elaborates on the concepts and methods informing the work of the working group to date, and describes the initial approach of the four subgroups studying generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobia. At present, the ENIGMA-Anxiety database contains information about more than 100 unique samples, from 16 countries and 59 institutes. Future directions include examining additional imaging modalities, integrating imaging and genetic data, and collaborating with other ENIGMA working groups. The ENIGMA consortium creates synergy at the intersection of global mental health and clinical neuroscience, and the ENIGMA-Anxiety Working Group extends the promise of this approach to neuroimaging research on anxiety disorders.
History
Publication status
- Published
File Version
- Published version
Journal
Human Brain MappingISSN
1065-9471Publisher
WileyExternal DOI
Issue
1Volume
43Page range
83-112Event location
United StatesDepartment affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-06-15First Open Access (FOA) Date
2022-06-15First Compliant Deposit (FCD) Date
2022-06-15Usage metrics
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