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Interplay between polygenic propensity for ageing-related traits and the consumption of fruits and vegetables on future dementia diagnosis
journal contribution
posted on 2023-06-10, 03:44 authored by Emma Ruby Francis, Dorina CadarDorina Cadar, Andrew Steptoe, Olesya AjnakinaBackground Understanding how polygenic scores for ageing-related traits interact with diet in determining a future dementia including Alzheimer’s diagnosis (AD) would increase our understanding of mechanisms underlying dementia onset. Methods Using 6784 population representative adults aged =50?years from the English Longitudinal Study of Ageing, we employed accelerated failure time survival model to investigate interactions between polygenic scores for AD (AD-PGS), schizophrenia (SZ-PGS) and general cognition (GC-PGS) and the baseline daily fruit and vegetable intake in association with dementia diagnosis during a 10-year follow-up. The baseline sample was obtained from waves 3–4 (2006–2009); follow-up data came from wave 5 (2010–2011) to wave 8 (2016–2017). Results Consuming
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- Published
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- Published version
Journal
BMC PsychiatryISSN
1471-244XPublisher
BMCExternal DOI
Issue
1Volume
22Page range
1-10Article number
a75Event location
EnglandDepartment affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-05-30First Open Access (FOA) Date
2022-05-30First Compliant Deposit (FCD) Date
2022-05-30Usage metrics
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