Harnessing cd8<sup>+</sup>cd28<sup>−</sup> regulatory t cells as a tool to treat autoimmune disease

Ceeraz, Sabrina, Thompson, Charlotte R, Beatson, Richard and Choy, Ernest H (2021) Harnessing cd8<sup>+</sup>cd28<sup>−</sup> regulatory t cells as a tool to treat autoimmune disease. Cells, 10 (11). a2973 1-11. ISSN 2073-4409

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Abstract

T regulatory cell therapy presents a novel therapeutic strategy for patients with autoimmune diseases or who are undergoing transplantation. At present, the CD4+ Treg population has been extensively characterized, as a result of defined phenotypic and functional readouts. In this review article, we discuss the development and biology of CD8+ Tregs and their role in murine and human disease indications. A subset of CD8+ Tregs that lack the surface expression of CD28 (CD8+CD28− Treg) has proved efficacious in preclinical models. CD8+CD28− Tregs are present in healthy individuals, but their impaired functionality in disease renders them less effective in mediating immunosuppression. We primarily focus on harnessing CD8+ Treg cell therapy in the clinic to support current treatment for patients with autoimmune or inflammatory conditions.

Item Type: Article
Keywords: CD8, Treg, autoimmunity, immunoregulation, Animals, Autoimmune Diseases, CD28 Antigens, CD8-Positive T-Lymphocytes, Humans, Immunosuppression Therapy, Immunotherapy, Adoptive, T-Lymphocytes, Regulatory
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 27 May 2022 15:41
Last Modified: 27 May 2022 15:45
URI: http://sro.sussex.ac.uk/id/eprint/106143

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