Formulation and quality control of Orally Disintegrating Tablets (ODTs): recent advances and perspectives

Ghourichay, Mohammadali Poursharifi, Kiaie, Seyed Hossein, Nokhodchi, Ali and Javadzadeh, Yousef (2021) Formulation and quality control of Orally Disintegrating Tablets (ODTs): recent advances and perspectives. BioMed Research International, 2021. a6618934 1-12. ISSN 2314-6133

[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (591kB)

Abstract

Orally disintegrating tablets (ODTs) rapidly disintegrate or dissolve in the oral cavity without using water. Demand for ODTs has increased, and the field has overgrown in the pharmaceutical industry and academia. It is reported that ODTs have several advantages over other conventional tablets. Since some of them are absorbed from the mouth, pharynx, and esophagus as the saliva passes down into the stomach, in such cases, the bioavailability of the drug improves meaningfully. Furthermore, the immediate release property of ODTs makes them a popular oral dosage form in patients with swallowing challenges, children, and for cases with a need for rapid onset of action. The current review article explains the features of active ingredients and excipients used in the formulation of ODTs, discusses multiple ODT formulation and preparation techniques with their merits and demerits, and also, offers remedies for problems associated with ODTs. Moreover, quality control steps and required considerations are presented.

Item Type: Article
Keywords: Administration, Oral, Animals, Biological Availability, Chemistry, Pharmaceutical, Excipients, Humans, Quality Control, Stomach, Tablets
Schools and Departments: School of Life Sciences > Chemistry
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 26 May 2022 12:15
Last Modified: 26 May 2022 12:16
URI: http://sro.sussex.ac.uk/id/eprint/106116

View download statistics for this item

📧 Request an update