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Formulation and quality control of Orally Disintegrating Tablets (ODTs): recent advances and perspectives
journal contribution
posted on 2023-06-10, 03:41 authored by Mohammadali Poursharifi Ghourichay, Seyed Hossein Kiaie, Ali Nokhodchi, Yousef JavadzadehOrally disintegrating tablets (ODTs) rapidly disintegrate or dissolve in the oral cavity without using water. Demand for ODTs has increased, and the field has overgrown in the pharmaceutical industry and academia. It is reported that ODTs have several advantages over other conventional tablets. Since some of them are absorbed from the mouth, pharynx, and esophagus as the saliva passes down into the stomach, in such cases, the bioavailability of the drug improves meaningfully. Furthermore, the immediate release property of ODTs makes them a popular oral dosage form in patients with swallowing challenges, children, and for cases with a need for rapid onset of action. The current review article explains the features of active ingredients and excipients used in the formulation of ODTs, discusses multiple ODT formulation and preparation techniques with their merits and demerits, and also, offers remedies for problems associated with ODTs. Moreover, quality control steps and required considerations are presented.
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Publication status
- Published
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- Published version
Journal
BioMed Research InternationalISSN
2314-6133Publisher
HindawiExternal DOI
Volume
2021Page range
1-12Article number
a6618934Event location
United StatesDepartment affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-05-26First Open Access (FOA) Date
2022-05-26First Compliant Deposit (FCD) Date
2022-05-26Usage metrics
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