Piccinin2022_Article_EquivalenceTestingOfANewlyDeve.pdf (536.03 kB)
Equivalence testing of a newly developed interviewer-led telephone script for the EORTC QLQ-C30
journal contribution
posted on 2023-06-10, 03:41 authored by Claire Piccinin, Madeline Pe, Dagmara Kulis, James W Shaw, Sally WheelwrightSally Wheelwright, Andrew BottomleyPurpose The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life-Core Questionnaire (QLQ-C30) is a widely used generic self-report measure of health-related quality of life (HRQOL) for cancer patients. However, no validated voice script for interviewer-led telephone administration was previously available. The aim of this study was to develop a voice script for interviewer administration via telephone. Methods Following guidelines from the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) PRO Mixed Modes Good Research Practices Task Force, a randomised cross-over equivalence study, including cognitive debriefing, was conducted to assess equivalence between paper and telephone administration modes. Assuming an expected intraclass correlation coefficient (ICC) of 0.70 and a minimally acceptable level of 0.50, a sample size of 63 was required. Results Cognitive interviews with five cancer patients found the voice script to be clear and understandable. Due to a protocol deviation in the first wave of testing, only 26 patients were available for analyses. A second wave of recruitment was conducted, adding 37 patients (n?=?63; mean age 55.48; 65.1% female). Total ICCs for mode comparison ranged from 0.72 (nausea and vomiting, 95% CI 0.48–0.86) to 0.90 (global health status/QoL, 95% CI 0.80–0.95; pain, 95% CI 0.79–0.95; constipation, 95% CI 0.80–0.95). For paper first administration, all ICCs were above 0.70, except nausea and vomiting (ICC 0.55; 95% CI 0.24–0.76) and financial difficulties (ICC 0.60; 95% CI 0.31–0.79). For phone first administration, all ICCs were above 0.70. Conclusions The equivalence testing results support the voice script’s validity for administration of the QLQ-C30 via telephone.
History
Publication status
- Published
File Version
- Published version
Journal
Quality of Life ResearchISSN
0962-9343Publisher
SpringerExternal DOI
Issue
3Volume
31Page range
877-888Event location
NetherlandsDepartment affiliated with
- Sussex Health Outcomes Research & Education in Cancer (SHORE-C) Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-05-26First Open Access (FOA) Date
2022-05-26First Compliant Deposit (FCD) Date
2022-05-26Usage metrics
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