Efficacy of low-fat milk and yogurt fortified with vitamin D<inf>3</inf> on systemic inflammation in adults with abdominal obesity

Sharifan, Payam, Rashidmayvan, Mohammad, Khorasanchi, Zahra, Darroudi, Susan, Heidari, Azam, Hoseinpoor, Fatemeh, Vatanparast, Hassan, Safarian, Mohamad, Eslami, Saeid, Afshari, Asma, Asadi, Zahra, Ghazizadeh, Hamideh, Bagherniya, Mohammad, Khedmatgozar, Hamed, Ferns, Gordon, Rezaie, Mitra and Mobarhan, Majid Ghayour (2022) Efficacy of low-fat milk and yogurt fortified with vitamin D<inf>3</inf> on systemic inflammation in adults with abdominal obesity. Journal of Health, Population and Nutrition, 41 (1). a8 1-8. ISSN 1606-0997

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Abstract

Background
The prevalence of vitamin D deficiency is increasing globally and is associated with an increased risk of metabolic syndrome, autoimmune disease, and cardiovascular disease. Vit D deficiency is also associated with increased systemic inflammation. The current study aimed to determine the efficacy of low-fat milk and yogurt fortified with 1500 IU nano-encapsulated vitamin D, on systemic inflammation in abdominal obese participants.

Method
This multi-center study was conducted using a 2.5-month parallel total-blind randomized clinical trial design. Two hundred and eighty nine subjects were allocated to four groups: low-fat milk fortified by 1500 IU nano-encapsulated vitamin D3 (200 mL/day). Simple milk (200 mL/day), low-fat yogurt fortified by 1500 IU nano-encapsulated vitamin D3 (150 g/day), and simple yogurt (150 g/day).

Results
The results showed that serum levels of neutrophils, lymphocytes, platelets and red blood cell distribution width (RDW) were significantly lower before and after the intervention in fortified dairy groups. The results showed that serum levels of neutrophils, lymphocytes, platelets, and RDW before and after intervention in the fortified dairy groups were significantly lower (p < 0.05). The values of = neutrophil to lymphocyte ratio (NLR), platelets to lymphocyte ratio, and RDW to platelets ratio (RPR) reduced significantly in the fortification group (p < 0.05).

Conclusion
Fortification with nano-encapsulated vitamin D3 of dairy products may decrease inflammation in individuals with abdominal obesity.

Item Type: Article
Keywords: Fortification, Inflammation, Low-fat dairy, Obesity, Vitamin D, Adult, Animals, Cholecalciferol, Food, Fortified, Humans, Inflammation, Milk, Obesity, Abdominal, Vitamin D, Vitamin D Deficiency, Yogurt
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 26 May 2022 08:58
Last Modified: 26 May 2022 08:58
URI: http://sro.sussex.ac.uk/id/eprint/106102

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