Amyloid PET imaging and dementias: potential applications in detecting and quantifying early white matter damage

Pietroboni, Anna M, Colombi, Annalisa, Carandini, Tiziana, Sacchi, Luca, Fenoglio, Chiara, Marotta, Giorgio, Arighi, Andrea, De Riz, Milena A, Fumagalli, Giorgio G, Castellani, Massimo, Bozzali, Marco, Scarpini, Elio and Galimberti, Daniela (2022) Amyloid PET imaging and dementias: potential applications in detecting and quantifying early white matter damage. Alzheimer's Research and Therapy, 14 (1). a33 1-8. ISSN 1758-9193

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Positron emission tomography (PET) with amyloid tracers (amy-PET) allows the quantification of pathological amyloid deposition in the brain tissues, including the white matter (WM). Here, we evaluate amy-PET uptake in WM lesions (WML) and in the normal-appearing WM (NAWM) of patients with Alzheimer’s disease (AD) and non-AD type of dementia.

Thirty-three cognitively impaired subjects underwent brain magnetic resonance imaging (MRI), Aβ1-42 (Aβ) determination in the cerebrospinal fluid (CSF) and amy-PET. Twenty-three patients exhibiting concordant results in both CSF analysis and amy-PET for cortical amyloid deposition were recruited and divided into two groups, amyloid positive (A+) and negative (A−). WML quantification and brain volumes’ segmentation were performed. Standardized uptake values ratios (SUVR) were calculated in the grey matter (GM), NAWM and WML on amy-PET coregistered to MRI images.

A+ compared to A− showed a higher WML load (p = 0.049) alongside higher SUVR in all brain tissues (p < 0.01). No correlations between CSF Aβ levels and WML and NAWM SUVR were found in A+, while, in A−, CSF Aβ levels were directly correlated to NAWM SUVR (p = 0.04). CSF Aβ concentration was the only predictor of NAWM SUVR (adj R2 = 0.91; p = 0.04) in A−. In A+ but not in A− direct correlations were identified between WM and GM SUVR (p < 0.01).

Our data provide evidence on the role of amy-PET in the assessment of microstructural WM injury in non-AD dementia, whereas amy-PET seems less suitable to assess WM damage in AD patients due to a plausible amyloid accrual therein.

Item Type: Article
Keywords: Alzheimer’s disease, Amyloid, Non-AD dementias, White matter, amy-PET, Alzheimer Disease, Amyloid, Amyloid beta-Peptides, Humans, Magnetic Resonance Imaging, Positron-Emission Tomography, White Matter
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 29 Apr 2022 15:27
Last Modified: 29 Apr 2022 15:30

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