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Amyloid PET imaging and dementias: potential applications in detecting and quantifying early white matter damage

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posted on 2023-06-10, 03:17 authored by Anna M Pietroboni, Annalisa Colombi, Tiziana Carandini, Luca Sacchi, Chiara Fenoglio, Giorgio Marotta, Andrea Arighi, Milena A De Riz, Giorgio G Fumagalli, Massimo Castellani, Marco Bozzali, Elio Scarpini, Daniela Galimberti
Purpose Positron emission tomography (PET) with amyloid tracers (amy-PET) allows the quantification of pathological amyloid deposition in the brain tissues, including the white matter (WM). Here, we evaluate amy-PET uptake in WM lesions (WML) and in the normal-appearing WM (NAWM) of patients with Alzheimer’s disease (AD) and non-AD type of dementia. Methods Thirty-three cognitively impaired subjects underwent brain magnetic resonance imaging (MRI), Aß1-42 (Aß) determination in the cerebrospinal fluid (CSF) and amy-PET. Twenty-three patients exhibiting concordant results in both CSF analysis and amy-PET for cortical amyloid deposition were recruited and divided into two groups, amyloid positive (A+) and negative (A-). WML quantification and brain volumes’ segmentation were performed. Standardized uptake values ratios (SUVR) were calculated in the grey matter (GM), NAWM and WML on amy-PET coregistered to MRI images. Results A+ compared to A- showed a higher WML load (p?=?0.049) alongside higher SUVR in all brain tissues (p?

History

Publication status

  • Published

File Version

  • Published version

Journal

Alzheimer's Research and Therapy

ISSN

1758-9193

Publisher

BMC

Issue

1

Volume

14

Page range

1-8

Article number

a33

Event location

England

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2022-04-29

First Open Access (FOA) Date

2022-04-29

First Compliant Deposit (FCD) Date

2022-04-29

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