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Amyloid PET imaging and dementias: potential applications in detecting and quantifying early white matter damage
journal contribution
posted on 2023-06-10, 03:17 authored by Anna M Pietroboni, Annalisa Colombi, Tiziana Carandini, Luca Sacchi, Chiara Fenoglio, Giorgio Marotta, Andrea Arighi, Milena A De Riz, Giorgio G Fumagalli, Massimo Castellani, Marco Bozzali, Elio Scarpini, Daniela GalimbertiPurpose Positron emission tomography (PET) with amyloid tracers (amy-PET) allows the quantification of pathological amyloid deposition in the brain tissues, including the white matter (WM). Here, we evaluate amy-PET uptake in WM lesions (WML) and in the normal-appearing WM (NAWM) of patients with Alzheimer’s disease (AD) and non-AD type of dementia. Methods Thirty-three cognitively impaired subjects underwent brain magnetic resonance imaging (MRI), Aß1-42 (Aß) determination in the cerebrospinal fluid (CSF) and amy-PET. Twenty-three patients exhibiting concordant results in both CSF analysis and amy-PET for cortical amyloid deposition were recruited and divided into two groups, amyloid positive (A+) and negative (A-). WML quantification and brain volumes’ segmentation were performed. Standardized uptake values ratios (SUVR) were calculated in the grey matter (GM), NAWM and WML on amy-PET coregistered to MRI images. Results A+ compared to A- showed a higher WML load (p?=?0.049) alongside higher SUVR in all brain tissues (p?
History
Publication status
- Published
File Version
- Published version
Journal
Alzheimer's Research and TherapyISSN
1758-9193Publisher
BMCExternal DOI
Issue
1Volume
14Page range
1-8Article number
a33Event location
EnglandDepartment affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-04-29First Open Access (FOA) Date
2022-04-29First Compliant Deposit (FCD) Date
2022-04-29Usage metrics
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