Combining liquisolid and co-grinding techniques to enhance the dissolution rate of celecoxib

Nazem, Nafiseh Mollazadeh, Shokri, Javad, Nourani, Nasim, Zangi, Ali Rajabi, Lam, Matthew, Nokhodchi, Ali and Javadzadeh, Yousef (2022) Combining liquisolid and co-grinding techniques to enhance the dissolution rate of celecoxib. Journal of Pharmaceutical Innovation. ISSN 1872-5120

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Abstract

Purpose
The classic liquisolid technique is used to enhance the dissolution rate of poorly water-soluble drugs, but in some cases, it is impossible to reach the desired dissolution rate using this technique alone. Therefore, a novel approach using a combination of ball milling and liquisolid technology was investigated to improve the dissolution rate for celecoxib.

Methods
First, celecoxib was dispersed in a liquid vehicle (PEG 200), then ground in a ball mill for 3 h. Other excipients, including PVP, microcrystalline cellulose as the carrier powder, and silica as the coating material, were added to the mortar. Dissolution testing was carried out in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF) media. The effects of aging on the hardness and dissolution profile were also studied. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) was used to identify changes in the crystallinity or complex formation.

Results
The novel formulations showed a higher dissolution rate than the conventional tablet or classic liquisolid formulations. Aging did not affect the hardness and dissolution profiles of the liquisolid compacts. The DSC and XRD results suggested that the enhanced dissolution rate is not caused by the formation of any complexes and reduction in crystallinity degree may contribute to the dissolution enhancement. The enhanced dissolution rate is attributed to the elevated specific surface area of the drug in the liquisolid state.

Conclusion
The results showed that liquisolid technology combined with ball milling is an efficient tool for enhancing the dissolution of poorly water-soluble drugs.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 21 Apr 2022 06:54
Last Modified: 21 Apr 2022 07:00
URI: http://sro.sussex.ac.uk/id/eprint/105414

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