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Magnetic field triggerable macroporous PDMS sponge loaded with an anticancer drug, 5-fluorouracil
journal contribution
posted on 2023-06-10, 03:12 authored by Kejing Shi, Rodrigo Amador Aviles-EspinosaRodrigo Amador Aviles-Espinosa, Elizabeth Rendon-MoralesElizabeth Rendon-Morales, Lisa Woodbine, Jonathan P Salvage, Mohammed Maniruzzaman, Ali NokhodchiThis study aims to prepare, optimize, and characterize magnetic-field-sensitive sugar-templated polydimethylsiloxane (PDMS) sponges for localized delivery of an anticancer drug, 5-fluorouracil (FLU). For this purpose, different concentrations of carbonyl iron (CI) and magnetite Fe3O4 nanopowders were embedded as magnetosensitive materials in PDMS resins for the fabrication of macroporous sponges via a sugar-template process. The process is environmentally friendly and simple. The fabricated interconnected macroporous magnetic particles loaded PDMS sponges possess flexible skeletons and good recyclability because of their recoverability after compression (deformation) without any breakdown. The prepared magnetic PDMS sponges were evaluated for their morphology (SEM and EDS), porosity (absorbency), elastic modulus, deformation under a magnetic field, thermostability, and in vitro cell studies. All physicochemical and magnetomechanical analysis confirmed that the optimized magnetic-field-sensitive PDMS sponge can provide an efficient method for delivering an on-demand dose of anticancer drug solutions at a specific location and timing with the aid of controlled magnetic fields.
History
Publication status
- Published
File Version
- Accepted version
Journal
ACS Biomaterials Science and EngineeringISSN
2373-9878Publisher
American Chemical SocietyExternal DOI
Issue
1Volume
7Page range
180-195Event location
United StatesDepartment affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2022-04-20First Compliant Deposit (FCD) Date
2022-05-27Usage metrics
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