Magnetic field triggerable macroporous PDMS sponge loaded with an anticancer drug, 5-fluorouracil

Shi, Kejing, Aviles-Espinosa, Rodrigo, Rendon-Morales, Elizabeth, Woodbine, Lisa, Salvage, Jonathan P, Maniruzzaman, Mohammed and Nokhodchi, Ali (2021) Magnetic field triggerable macroporous PDMS sponge loaded with an anticancer drug, 5-fluorouracil. ACS Biomaterials Science and Engineering, 7 (1). pp. 180-195. ISSN 2373-9878

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Abstract

This study aims to prepare, optimize, and characterize magnetic-field-sensitive sugar-templated polydimethylsiloxane (PDMS) sponges for localized delivery of an anticancer drug, 5-fluorouracil (FLU). For this purpose, different concentrations of carbonyl iron (CI) and magnetite Fe3O4 nanopowders were embedded as magnetosensitive materials in PDMS resins for the fabrication of macroporous sponges via a sugar-template process. The process is environmentally friendly and simple. The fabricated interconnected macroporous magnetic particles loaded PDMS sponges possess flexible skeletons and good recyclability because of their recoverability after compression (deformation) without any breakdown. The prepared magnetic PDMS sponges were evaluated for their morphology (SEM and EDS), porosity (absorbency), elastic modulus, deformation under a magnetic field, thermostability, and in vitro cell studies. All physicochemical and magnetomechanical analysis confirmed that the optimized magnetic-field-sensitive PDMS sponge can provide an efficient method for delivering an on-demand dose of anticancer drug solutions at a specific location and timing with the aid of controlled magnetic fields.

Item Type: Article
Keywords: 5-fluorouracil, Magnetic field, carbonyl iron, iron oxide, nanoparticles, personalized medicine, polydimethylsiloxane, sponge, triggerable drug delivery system, Antineoplastic Agents, Dimethylpolysiloxanes, Fluorouracil, Magnetic Fields, Porosity
Schools and Departments: School of Life Sciences > Chemistry
School of Life Sciences > Sussex Centre for Genome Damage and Stability
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 20 Apr 2022 11:37
Last Modified: 27 May 2022 07:45
URI: http://sro.sussex.ac.uk/id/eprint/105370

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