BSR-2021-1841CR1_Merged_PDF.pdf (7.41 MB)
Targeting ß-catenin in acute myeloid leukaemia: past, present, and future perspectives
journal contribution
posted on 2023-06-10, 03:06 authored by Megan Wagstaff, Brandon Coke, Georgia R Hodgkiss, Rhys MorganRhys MorganAcute myeloid leukaemia (AML) is an aggressive disease of the bone marrow with a poor prognosis. Evidence suggests long established chemotherapeutic regimens used to treat AML are reaching the limits of their efficacy, necessitating the urgent development of novel targeted therapies. Canonical Wnt signalling is an evolutionary conserved cascade heavily implicated in normal developmental and disease processes in humans. For over 15 years it's been known that the central mediator of this pathway, ß-catenin, is dysregulated in AML promoting the emergence, maintenance, and drug resistance of leukaemia stem cells (LSC). Yet, despite this knowledge, and subsequent studies demonstrating the therapeutic potential of targeting Wnt activity in haematological cancers, ß-catenin inhibitors have not yet reached the clinic. The aim of this review is to summarise the current understanding regarding the role and mechanistic dysregulation of ß-catenin in AML and assess the therapeutic merit of pharmacologically targeting this molecule, drawing on lessons from other disease contexts.
History
Publication status
- Published
File Version
- Accepted version
Journal
Bioscience ReportsISSN
0144-8463Publisher
Portland PressExternal DOI
Event location
EnglandDepartment affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-04-08First Open Access (FOA) Date
2022-04-08First Compliant Deposit (FCD) Date
2022-04-08Usage metrics
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