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The Greek goddess, Artemis, reveals the secrets of her cleavage

journal contribution
posted on 2023-06-07, 13:55 authored by Penny Jeggo, P O'Neill
A recent paper in Cell by Ma et al. [Cell 8 (2002) 781] showed that the protein Artemis cleaves a hairpin intermediate during V(D)J recombination. Peter O'Neill and Penny Jeggo discuss this finding in the light of evidence that Artemis also functions to repair radiation damage [Cell 105 (2001) 177]. The findings suggest that Artemis may function in double strand break repair by ''tidying up'' double strand ends with associated base damage. The development of genetic diversity during immune development, therefore, seems to exploit damage response mechanisms that function to maintain genetic stability in other cell lineages.

History

Publication status

  • Published

Journal

DNA Repair

ISSN

1568-7864

Issue

9

Volume

1

Page range

771-777

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2007-04-04

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