The Greek goddess, Artemis, reveals the secrets of her cleavage

Jeggo, P. A. and O'Neill, P (2002) The Greek goddess, Artemis, reveals the secrets of her cleavage. DNA Repair, 67. pp. 1-7. ISSN 1568-7864

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A recent paper in Cell by Ma et al. [Cell 8 (2002) 781] showed that the protein Artemis cleaves a hairpin intermediate during V(D)J recombination. Peter O'Neill and Penny Jeggo discuss this finding in the light of evidence that Artemis also functions to repair radiation damage [Cell 105 (2001) 177]. The findings suggest that Artemis may function in double strand break repair by ''tidying up'' double strand ends with associated base damage. The development of genetic diversity during immune development, therefore, seems to exploit damage response mechanisms that function to maintain genetic stability in other cell lineages.

Item Type: Article
Additional Information: GDSC23
Schools and Departments: School of Life Sciences
Depositing User: Gee Wheatley
Date Deposited: 04 Apr 2007
Last Modified: 30 Nov 2012 16:51
Google Scholar:50 Citations
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