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The Greek goddess, Artemis, reveals the secrets of her cleavage
journal contribution
posted on 2023-06-07, 13:55 authored by Penny Jeggo, P O'NeillA recent paper in Cell by Ma et al. [Cell 8 (2002) 781] showed that the protein Artemis cleaves a hairpin intermediate during V(D)J recombination. Peter O'Neill and Penny Jeggo discuss this finding in the light of evidence that Artemis also functions to repair radiation damage [Cell 105 (2001) 177]. The findings suggest that Artemis may function in double strand break repair by ''tidying up'' double strand ends with associated base damage. The development of genetic diversity during immune development, therefore, seems to exploit damage response mechanisms that function to maintain genetic stability in other cell lineages.
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Publication status
- Published
Journal
DNA RepairISSN
1568-7864External DOI
Issue
9Volume
1Page range
771-777Full text available
- No
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- Yes
Legacy Posted Date
2007-04-04Usage metrics
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