The Greek goddess, Artemis, reveals the secrets of her cleavage

Jeggo, P. A. and O'Neill, P (2002) The Greek goddess, Artemis, reveals the secrets of her cleavage. DNA Repair, 1 (9). pp. 771-777. ISSN 1568-7864

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A recent paper in Cell by Ma et al. [Cell 8 (2002) 781] showed that the protein Artemis cleaves a hairpin intermediate during V(D)J recombination. Peter O'Neill and Penny Jeggo discuss this finding in the light of evidence that Artemis also functions to repair radiation damage [Cell 105 (2001) 177]. The findings suggest that Artemis may function in double strand break repair by ''tidying up'' double strand ends with associated base damage. The development of genetic diversity during immune development, therefore, seems to exploit damage response mechanisms that function to maintain genetic stability in other cell lineages.

Item Type: Article
Depositing User: Gee Wheatley
Date Deposited: 04 Apr 2007
Last Modified: 16 Sep 2019 08:29
Google Scholar:50 Citations
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