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Additive manufacturing of bio-inspired ceramic bone scaffolds: structural design, mechanical properties and biocompatibility
Version 2 2023-06-12, 07:45
Version 1 2023-06-10, 03:02
journal contribution
posted on 2023-06-12, 07:45 authored by Chen Jiao, Deqiao Xie, Zhijing He, Huixin Liang, Lida Shen, Youwen Yang, Zongjun Tian, Guofeng Wu, Chang WangChang WangIdeal bone scaffolds require good biocompatibility and moderate mechanical properties, so as to promote the proliferation and differentiation of osteoblast cells, and achieve the good bone repair. Inspired by the porous structure of cancellous bone, 15 groups of bone scaffolds with variable irregularity (Ir1-5) and porosity (35.53-61.75%) were designed and fabricated by ceramic digital light processing (DLP) using 20 wt.% hydroxyapatite doped zirconia as the matrix material. The effects of structural parameters and material on mechanical properties and biocompatibility were studied. The shrinkage test results showed that the density of scaffolds was mainly affected by the porosity. The mechanical test results showed that Ir2 and Ir3 scaffolds had better compressive behaviors, and the compressive strength could be increased by 30% by regulating the irregularity. All scaffolds showed comparable mechanical properties to that of cancellous bone. Cell experiments showed that the effect of structure on cell proliferation, differentiation, and mineralization was most evident at the early stage of implantation. Meanwhile, the biocompatibility variation with the irregularity was consistent with mechanical properties. This study proved that a bio-inspired bone scaffold with excellent comprehensive properties could be obtained through reasonable design.
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Publication status
- Published
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- Published version
Journal
Materials & DesignISSN
0264-1275Publisher
ElsevierExternal DOI
Volume
217Page range
1-12Article number
a110610Department affiliated with
- Engineering and Design Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-04-04First Open Access (FOA) Date
2022-04-04First Compliant Deposit (FCD) Date
2022-04-01Usage metrics
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