Livermore2022_Article_ASingleOralDoseOfCitalopramInc.pdf (862.65 kB)
A single oral dose of citalopram increases interoceptive insight in healthy volunteers
Version 2 2023-06-12, 07:44
Version 1 2023-06-10, 02:54
journal contribution
posted on 2023-06-12, 07:44 authored by James Livermore, Clare L Holmes, Gyorgy Moga, Kristian Adamatzky, Hugo CritchleyHugo Critchley, Sarah Garfinkel, Dan Campbell-MeiklejohnDan Campbell-MeiklejohnRationale Interoception is the signalling, perception, and interpretation of internal physiological states. Many mental disorders associated with changes of interoception, including depressive and anxiety disorders, are treated with selective serotonin reuptake inhibitors (SSRIs). However, the causative link between SSRIs and interoception is not yet clear. Objectives To ascertain the causal effect of acute changes of serotonin levels on cardiac interoception. Methods Using a within-participant placebo-controlled design, forty-seven healthy human volunteers (31 female, 16 male) were tested on and off a 20 mg oral dose of the commonly prescribed SSRI, citalopram. Participants made judgements on the synchrony between their heartbeat and auditory tones and then expressed confidence in each judgement. We measured three types of interoceptive cognition. Results Citalopram increased cardiac interoceptive insight, measured as correspondence of self-reported confidence to the likelihood that interoceptive judgements were actually correct. This effect was driven by enhanced confidence for correct interoceptive judgements and was independent of measured cardiac and reported subjective effects of the drug. Conclusions An acute change of serotonin levels can increase insight into the reliability of inferences made from cardiac interoceptive sensations.
History
Publication status
- Published
File Version
- Published version
Journal
PsychopharmacologyISSN
0033-3158Publisher
SpringerExternal DOI
Department affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-03-15First Open Access (FOA) Date
2022-04-11First Compliant Deposit (FCD) Date
2022-03-14Usage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC