Extracellular vesicles as mediators of therapy resistance in breast cancer microenvironment

Samuels, Mark, Cilibrasi, Chiara, Papanastasopoulos, Panagiotis and Giamas, Georgios (2022) Extracellular vesicles as mediators of therapy resistance in breast cancer microenvironment. Biomolecules, 12 (1). pp. 1-40. ISSN 2218-273X

[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (3MB)


Resistance to various therapies, including novel immunotherapies, poses a major challenge in the management of breast cancer and is the leading cause of treatment failure. Bidirectional communication between breast cancer cells and the tumour microenvironment is now known to be an important contributor to therapy resistance. Several studies have demonstrated that crosstalk with the tumour microenvironment through extracellular vesicles is an important mechanism employed by cancer cells that leads to drug resistance via changes in protein, lipid and nucleic acid cargoes. Moreover, the cargo content enables extracellular vesicles to be used as effective biomarkers for predicting response to treatments and as potential therapeutic targets. This review summarises the literature to date regarding the role of extracellular vesicles in promoting therapy resistance in breast cancer through communication with the tumour microenvironment.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science
Depositing User: Georgios Giamas
Date Deposited: 20 Jan 2022 10:14
Last Modified: 20 Jan 2022 10:15
URI: http://sro.sussex.ac.uk/id/eprint/103907

View download statistics for this item

📧 Request an update