ijms-22-12015-v3.pdf (1.77 MB)
Reconstituting immune surveillance in breast cancer: molecular pathophysiology and current immunotherapy strategies
journal contribution
posted on 2023-06-10, 02:23 authored by Chiara Cilibrasi, Panagiotis Papanastasopoulos, Mark SamuelsMark Samuels, Georgios GiamasGeorgios GiamasOver the past 50 years, breast cancer immunotherapy has emerged as an active field of research, generating novel, targeted treatments for the disease. Immunotherapies carry enormous potential to improve survival in breast cancer, particularly for the subtypes carrying the poorest prognoses. Here, we review the mechanisms by which cancer evades immune destruction as well as the history of breast cancer immunotherapies and recent developments, including clinical trials that have shaped the treatment of the disease with a focus on cell therapies, vaccines, checkpoint inhibitors, and oncolytic viruses.
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- Published
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- Published version
Journal
International Journal of Molecular SciencesISSN
1661-6596Publisher
MDPIExternal DOI
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21Volume
22Page range
1-20Article number
a12015Department affiliated with
- Biochemistry Publications
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- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-01-20First Open Access (FOA) Date
2022-01-20First Compliant Deposit (FCD) Date
2022-01-20Usage metrics
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