Cilibrasi, Chiara, Papanastasopoulos, Panagiotis, Samuels, Mark and Giamas, Georgios (2021) Reconstituting immune surveillance in breast cancer: molecular pathophysiology and current immunotherapy strategies. International Journal of Molecular Sciences, 22 (21). a12015 1-20. ISSN 1661-6596

PDF - Published Version Available under License Creative Commons Attribution. Download (1MB)

Abstract

Over the past 50 years, breast cancer immunotherapy has emerged as an active field of research, generating novel, targeted treatments for the disease. Immunotherapies carry enormous potential to improve survival in breast cancer, particularly for the subtypes carrying the poorest prognoses. Here, we review the mechanisms by which cancer evades immune destruction as well as the history of breast cancer immunotherapies and recent developments, including clinical trials that have shaped the treatment of the disease with a focus on cell therapies, vaccines, checkpoint inhibitors, and oncolytic viruses.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Biochemistry
Subjects:	Q Science
Depositing User:	Georgios Giamas
Date Deposited:	20 Jan 2022 08:47
Last Modified:	20 Jan 2022 08:47
URI:	http://sro.sussex.ac.uk/id/eprint/103903

View download statistics for this item

📧 Request an update