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Serum level of high sensitive C-reactive protein and IL - 6 markers in patients with treatment-resistant schizophrenia in Ethiopia: a comparative study
journal contribution
posted on 2023-06-10, 02:21 authored by Feyissa Challa, Daniel Seifu, Meron Sileshi, Tigist Getahun, Zeleke Geto, Desta Kassa, Melkam Alemayehu, Miraf Mesfin, Abe WassieAbe Wassie, Yimtubezinash WoldeamanuelBackground Accumulating evidence indicates that schizophrenia is accompanied by significant activation of the immune system; however, there is limited data from low and middle-income countries (LMIC). Inflammatory markers may be more relevant in LMIC settings where infectious conditions are more prevalent and may thus play some role in the causation and maintenance of schizophrenia. The aim of this study was to assess the level of inflammatory markers high sensitive C-reactive protein (hsCRP) and interleukin-6 (IL-6) in patients with schizophrenia. Materials and methods The study population consisted of a total of 132 study participants; 82 participants with schizophrenia and 50 controls. hsCRP and IL-6 were measured using Cobas Integra 400 Plus and Cobas e 411 analysers respectively. Results The levels of hsCRP and IL-6 were significantly increased among participants with schizophrenia compared to controls: hsCRP mean value 2.87?±?5.6 vs 0.67?±?0.6?mg/L; IL-6 mean value 6.63?±?5.6 vs 3.37?±?4.0?pg/ml. Controlling for potential confounders (age, sex and body mass index), having a diagnosis of schizophrenia remained significantly associated with increased hsCRP and IL-6. Conclusion The results confirm that inflammatory processes may have a role in the pathophysiology of schizophrenia regardless of setting. Despite failure of some interventions with anti-inflammatory properties, interventions to reduce inflammation are still worth pursuing.
History
Publication status
- Published
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- Published version
Journal
BMC PsychiatryISSN
1471-244XPublisher
BMCExternal DOI
Issue
1Volume
21Page range
1-8Article number
a428Event location
EnglandDepartment affiliated with
- Global Health and Infection Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-01-17First Open Access (FOA) Date
2022-01-17First Compliant Deposit (FCD) Date
2022-01-17Usage metrics
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