1-s2.0-S0753332221010313-main.pdf (1.74 MB)
Role of microRNAs in COVID-19 with implications for therapeutics
journal contribution
posted on 2023-06-10, 02:20 authored by Nahid Arghiani, Tracy Nissan, Maryam M MatinCOVID-19 is a pneumonia-like disease with highly transmittable and pathogenic properties caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infects both animals and humans. Although many efforts are currently underway to test possible therapies, there is no specific FDA approved drug against SARS-CoV-2 yet. miRNA-directed gene regulation controls the majority of biological processes. In addition, the development and progression of several human diseases are associated with dysregulation of miRNAs. In this regard, it has been shown that changes in miRNAs are linked to severity of COVID-19 especially in patients with respiratory diseases, diabetes, heart failure or kidney problems. Therefore, targeting these small noncoding-RNAs could potentially alleviate complications from COVID-19. Here, we will review the roles and importance of host and RNA virus encoded miRNAs in COVID-19 pathogenicity and immune response. Then, we focus on potential miRNA therapeutics in the patients who are at increased risk for severe disease.
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Publication status
- Published
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- Published version
Journal
Biomedicine and PharmacotherapyISSN
0753-3322Publisher
ElsevierExternal DOI
Volume
144Page range
1-10Article number
a112247Event location
FranceDepartment affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-01-17First Open Access (FOA) Date
2022-01-17First Compliant Deposit (FCD) Date
2022-01-17Usage metrics
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