Role of microRNAs in COVID-19 with implications for therapeutics

Arghiani, Nahid, Nissan, Tracy and Matin, Maryam M (2021) Role of microRNAs in COVID-19 with implications for therapeutics. Biomedicine and Pharmacotherapy, 144. a112247 1-10. ISSN 0753-3322

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Abstract

COVID-19 is a pneumonia-like disease with highly transmittable and pathogenic properties caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infects both animals and humans. Although many efforts are currently underway to test possible therapies, there is no specific FDA approved drug against SARS-CoV-2 yet. miRNA-directed gene regulation controls the majority of biological processes. In addition, the development and progression of several human diseases are associated with dysregulation of miRNAs. In this regard, it has been shown that changes in miRNAs are linked to severity of COVID-19 especially in patients with respiratory diseases, diabetes, heart failure or kidney problems. Therefore, targeting these small noncoding-RNAs could potentially alleviate complications from COVID-19. Here, we will review the roles and importance of host and RNA virus encoded miRNAs in COVID-19 pathogenicity and immune response. Then, we focus on potential miRNA therapeutics in the patients who are at increased risk for severe disease.

Item Type: Article
Keywords: Anti-miRNA therapy, Coronavirus, SARS-CoV-2, miRNA therapy, miRNAs, Animals, Antiviral Agents, COVID-19, Drug Delivery Systems, Genetic Therapy, Humans, MicroRNAs
Schools and Departments: School of Life Sciences > Biochemistry
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 17 Jan 2022 14:33
Last Modified: 17 Jan 2022 14:45
URI: http://sro.sussex.ac.uk/id/eprint/103881

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