biomedicines-09-00975-v4.pdf (10.12 MB)
Metronidazole-and amoxicillin-loaded plga and pcl nanofibers as potential drug delivery systems for the treatment of periodontitis: in vitro and in vivo evaluations
journal contribution
posted on 2023-06-10, 02:19 authored by Shahla Mirzaeei, Mahla Mansurian, Kofi Asare-Addo, Ali NokhodchiThe purpose of this study was to prepare poly (D-L) lactide-co-glycolide (PLGA) and poly e-caprolactone (PCL) nanofibers containing metronidazole and amoxicillin using an electrospinning process as intrapocket sustained-release drug delivery systems for the treatment of periodontal diseases. Scanning electron microscopy showed that the drug containing PLGA and PCL nanofibers produced from the electrospinning process was uniform and bead-free in morphology. The obtained nanofibers had a strong structure and resisted external tension according to the tensiometry results. The cytotoxicity results indicated acceptable cell viability (>80%). Quantification by high-performance liquid chromatography showed almost complete in vitro drug release between 7 and 9 days, whereas 14 days were required for complete drug release in vivo. No significant signs of irritation or inflammatory reaction were detected after three weeks of subcutaneous implantation of nanofibers in the animal models, thus indicating suitable compatibility. The results therefore suggest that the designed nanofibers can be used as potential commercial formulations in the treatment of periodontitis as controlled-release intrapocket drug delivery systems that can increase patient compliance. This is due to their ability to reduce the frequency of administration from three times daily in a systemic manner to once weekly as local delivery.
History
Publication status
- Published
File Version
- Published version
Journal
BiomedicinesISSN
2227-9059Publisher
MDPIExternal DOI
Issue
8Volume
9Page range
1-17Article number
a975Event location
SwitzerlandDepartment affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-01-17First Open Access (FOA) Date
2022-01-17First Compliant Deposit (FCD) Date
2022-01-17Usage metrics
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