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Metronidazole-and amoxicillin-loaded plga and pcl nanofibers as potential drug delivery systems for the treatment of periodontitis: in vitro and in vivo evaluations

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posted on 2023-06-10, 02:19 authored by Shahla Mirzaeei, Mahla Mansurian, Kofi Asare-Addo, Ali Nokhodchi
The purpose of this study was to prepare poly (D-L) lactide-co-glycolide (PLGA) and poly e-caprolactone (PCL) nanofibers containing metronidazole and amoxicillin using an electrospinning process as intrapocket sustained-release drug delivery systems for the treatment of periodontal diseases. Scanning electron microscopy showed that the drug containing PLGA and PCL nanofibers produced from the electrospinning process was uniform and bead-free in morphology. The obtained nanofibers had a strong structure and resisted external tension according to the tensiometry results. The cytotoxicity results indicated acceptable cell viability (>80%). Quantification by high-performance liquid chromatography showed almost complete in vitro drug release between 7 and 9 days, whereas 14 days were required for complete drug release in vivo. No significant signs of irritation or inflammatory reaction were detected after three weeks of subcutaneous implantation of nanofibers in the animal models, thus indicating suitable compatibility. The results therefore suggest that the designed nanofibers can be used as potential commercial formulations in the treatment of periodontitis as controlled-release intrapocket drug delivery systems that can increase patient compliance. This is due to their ability to reduce the frequency of administration from three times daily in a systemic manner to once weekly as local delivery.

History

Publication status

  • Published

File Version

  • Published version

Journal

Biomedicines

ISSN

2227-9059

Publisher

MDPI

Issue

8

Volume

9

Page range

1-17

Article number

a975

Event location

Switzerland

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2022-01-17

First Open Access (FOA) Date

2022-01-17

First Compliant Deposit (FCD) Date

2022-01-17

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