Encapsulation of bacteriophage cocktail into chitosan for the treatment of bacterial diarrhea

Rahimzadeh, Golnar, Saeedi, Majid, Moosazadeh, Mahmood, Hashemi, Seyyed Mohammad Hassan, Babaei, Amirhossein, Rezai, Mohammad Sadegh, Kamel, Kosar, Asare-Addo, Kofi and Nokhodchi, Ali (2021) Encapsulation of bacteriophage cocktail into chitosan for the treatment of bacterial diarrhea. Scientific Reports, 11 (1). a15603 1-10. ISSN 2045-2322

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Abstract

The therapeutic effectiveness of a chitosan encapsulated bacteriophage cocktail as a smart biocontrol agent was evaluated in this study to be used as a preventative and treatment option for gastrointestinal infections. To evaluate the effect of the bacteriophage formulation on the treatment of gastrointestinal infection, rats were infected with Salmonella enterica, Shigella flexneri, and Escherichia coli. The rats were weighed and their stools cultured. The results showed that the group which had the chitosan encapsulated bacteriophage cocktail did not lose weight after 3 days and had significantly lower group weight changes. Weight loss was significant in the rats that had cefixime administered instead. Positive cultured stools were reduced after 4 days compared to 2 days in the treated group with the chitosan encapsulated bacteriophage cocktail. The chitosan encapsulated bacteriophage cocktail can therefore be effective in the treatment of gastrointestinal infections.

Item Type: Article
Keywords: Bacteriophages, Chitosan, Food Microbiology, Shigella flexneri
Schools and Departments: School of Life Sciences > Chemistry
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 14 Jan 2022 15:25
Last Modified: 14 Jan 2022 15:30
URI: http://sro.sussex.ac.uk/id/eprint/103835

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