s41598-021-95132-1.pdf (2.13 MB)
Encapsulation of bacteriophage cocktail into chitosan for the treatment of bacterial diarrhea
journal contribution
posted on 2023-06-10, 02:18 authored by Golnar Rahimzadeh, Majid Saeedi, Mahmood Moosazadeh, Seyyed Mohammad Hassan Hashemi, Amirhossein Babaei, Mohammad Sadegh Rezai, Kosar Kamel, Kofi Asare-Addo, Ali NokhodchiThe therapeutic effectiveness of a chitosan encapsulated bacteriophage cocktail as a smart biocontrol agent was evaluated in this study to be used as a preventative and treatment option for gastrointestinal infections. To evaluate the effect of the bacteriophage formulation on the treatment of gastrointestinal infection, rats were infected with Salmonella enterica, Shigella flexneri, and Escherichia coli. The rats were weighed and their stools cultured. The results showed that the group which had the chitosan encapsulated bacteriophage cocktail did not lose weight after 3 days and had significantly lower group weight changes. Weight loss was significant in the rats that had cefixime administered instead. Positive cultured stools were reduced after 4 days compared to 2 days in the treated group with the chitosan encapsulated bacteriophage cocktail. The chitosan encapsulated bacteriophage cocktail can therefore be effective in the treatment of gastrointestinal infections.
History
Publication status
- Published
File Version
- Published version
Journal
Scientific ReportsISSN
2045-2322Publisher
Nature ResearchExternal DOI
Issue
1Volume
11Page range
1-10Article number
a15603Event location
EnglandDepartment affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-01-14First Open Access (FOA) Date
2022-01-14First Compliant Deposit (FCD) Date
2022-01-14Usage metrics
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